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Comment
. 2018 Jan 4;22(1):7-9.
doi: 10.1016/j.stem.2017.12.006.

Think About the Environment: Cellular Reprogramming by the Extracellular Matrix

David J Huels  1 , Jan Paul Medema  2
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Think About the Environment: Cellular Reprogramming by the Extracellular Matrix

David J Huels et al. Cell Stem Cell. .
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Abstract

In this issue of Cell Stem Cell, Yui et al. (2018) show how tissue regeneration is driven by changes in the microenvironment. During intestinal regeneration, the epithelium is reprogrammed into a fetal state by an altered extracellular matrix (ECM), which is dependent on YAP/TAZ activation.

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