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. 2018 Mar;28(3):173-175.
doi: 10.1016/j.tcb.2017.12.003. Epub 2018 Jan 2.

Notching a New Pathway in Vascular Flow Sensing

Anne K Lagendijk  1 , Alpha S Yap  2 , Benjamin M Hogan  3
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Notching a New Pathway in Vascular Flow Sensing

Anne K Lagendijk et al. Trends Cell Biol. 2018 Mar.

Abstract

Vascular barrier function is controlled at cell-cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms controlling the endothelial barrier.

Keywords: Notch; VE-cadherin; endothelial; endothelial barrier; vascular.

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