An Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

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No authors listed. Cancer Discov. 2018 Feb.

. 2018 Feb;8(2):138.

doi: 10.1158/2159-8290.CD-RW2018-003. Epub 2018 Jan 5.

Abstract

Stress-activated ADRB2 signaling promotes tumor innervation and PDAC development.

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.
Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, Ilmer M, Valenti G, Mohanta SK, Habenicht AJR, Middelhoff M, Chu T, Nagar K, Tailor Y, Casadei R, Di Marco M, Kleespies A, Friedman RA, Remotti H, Reichert M, Worthley DL, Neumann J, Werner J, Iuga AC, Olive KP, Wang TC. Renz BW, et al. Cancer Cell. 2018 Jan 8;33(1):75-90.e7. doi: 10.1016/j.ccell.2017.11.007. Epub 2017 Dec 14. Cancer Cell. 2018. PMID: 29249692 Free PMC article.