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Review
. 2018 Jan;109(1):33-38.
doi: 10.1016/j.fertnstert.2017.12.004.

BRCA mutations and reproduction

Hagit Daum  1 , Tamar Peretz  2 , Neri Laufer  3
Affiliations
Free article
Review

BRCA mutations and reproduction

Hagit Daum et al. Fertil Steril. 2018 Jan.
Free article

Abstract

Deleterious mutations in BRCA1 or BRCA2 genes have long been recognized as independent risk factors, mostly for breast and ovarian cancer. Numerous studies have evaluated the molecular processes involving these genes, the pathophysiology of BRCAness, follow up options and modes of prophylaxis. The fertility of BRCA carriers, however, has not been widely investigated. The aim of the present work is to review the literature pertaining to this issue.

Keywords: BRCA; preimplantation genetic diagnosis (PGD); premature ovarian insufficiency.

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