Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Oct-Dec;7(4):264-265.
doi: 10.4103/ijabmr.IJABMR_469_16.

Retinoic Acid Embryopathy

Dipankar Mondal  1 , Sreekanth R Shenoy  1 , Santisena Mishra  1
Affiliations
Case Reports

Retinoic Acid Embryopathy

Dipankar Mondal et al. Int J Appl Basic Med Res. 2017 Oct-Dec.

Abstract

Isotretinoin is a retinoid which is derived from Vitamin A. It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have been described with prenatal exposure to this drug. We report the case of a newborn with a history of prenatal exposure to isotretinoin with craniofacial defects, including left-sided anotia, right-sided microtia, complex congenital heart disease, and central nervous system malformation.

Keywords: Anotia; central nervous system malformation; congenital heart disease; isotretinoin; microtia; teratogenic.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Microtia of the right ear and anotia with preauricular tag of the left ear
See this image and copyright information in PMC

References

    1. Wilson RD, Johnson JA, Summers A, Wyatt P, Allen V, Gagnon A, et al. Principles of human teratology: Drug, chemical, and infectious exposure. J Obstet Gynaecol Can. 2007;29:911–26. - PubMed
    1. Jones KL, Jones MC, Campo MD. Smith's recognizable patterns of human malformation. 7th Edition. Elsevier Saunders; 2013. Retinoic Acid Embryopathy; pp. 742–43.
    1. Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, et al. Retinoic acid embryopathy. N Engl J Med. 1985;313:837–41. - PubMed
    1. Dai WS, LaBraico JM, Stern RS. Epidemiology of isotretinoin exposure during pregnancy. J Am Acad Dermatol. 1992;26:599–606. - PubMed
    1. Lee SM, Kim HM, Lee JS, Yoon CS, Park MS, Park KI, et al. Acase of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug. Yonsei Med J. 2009;50:445–7. - PMC - PubMed

Publication types