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. 2019 Mar 28;8(1):69-72.
doi: 10.1093/jpids/pix103.

Oral Fluoroquinolone Administration and Interacting Substances: The Pediatric Diet Dilemma

Jeffrey L Butler  1 , Amanda L Hurst  1
Affiliations

Oral Fluoroquinolone Administration and Interacting Substances: The Pediatric Diet Dilemma

Jeffrey L Butler et al. J Pediatric Infect Dis Soc. .

Abstract

Concomitant administration of enteral fluoroquinolones (FQs) with divalent or trivalent cation-containing compounds results in a reduction in FQ bioavailability. A review of enteral FQ administration with regards to the timing of divalent or trivalent cation-containing compounds in pediatric patients revealed a high number of inappropriately administered FQs. Suggestions for reducing the number of inappropriately timed FQ administrations are presented here.

Keywords: absorption; cation; fluoroquinolone; interaction; pediatrics.

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