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. 2018 Jun 21;39(24):2326-2329.
doi: 10.1093/eurheartj/ehx775.

The circadian clock in cardiovascular regulation and disease: Lessons from the Nobel Prize in Physiology or Medicine 2017

Linda W Van Laake  1 , Thomas F Lüscher  2 , Martin E Young  3
Affiliations

The circadian clock in cardiovascular regulation and disease: Lessons from the Nobel Prize in Physiology or Medicine 2017

Linda W Van Laake et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
The Nobel Laureates 2017. (From left to right): Jeffrey C. Hall, Michael Rosbash, and Michael W. Young.
Figure 2
Figure 2
The molecular circadian clock and cardiology. The molecular circadian clock, of which a simplified version is schematically depicted in the centre, sustains a 24-h rhythm that has impact on several facets of cardiology.
Figure 3
Figure 3
Crucial impact of circadian rhythms on cardiology: a translational vision. The circadian clock crucially affects stress tolerance in human stem cell-derived cardiomyocytes and progenitor cells (mechanistic platform; figure modified from Dierickx et al.8), mouse cardiomyocytes in an ischaemia-reperfusion model (bridging translational step), and human cardiomyocytes in aortic valve replacement surgery with impact on clinical outcome (clinical application). MI, myocardial infarction.
See this image and copyright information in PMC

References

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    1. Martino TA, Young ME.. Influence of the cardiomyocyte circadian clock on cardiac physiology and pathophysiology. J Biol Rhythms 2015;30:183–205. - PubMed

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