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Review
. 2018 Jan:220:49-76.
doi: 10.1016/j.cancergen.2017.11.001. Epub 2017 Nov 15.

Decoding colorectal cancer epigenomics

Khalid El Bairi  1 , Kanwal Tariq  2 , Imane Himri  3 , Abdeslam Jaafari  4 , Wiam Smaili  5 , Abdul Hafeez Kandhro  6 , Adel Gouri  7 , Bouchra Ghazi  8
Affiliations
Review

Decoding colorectal cancer epigenomics

Khalid El Bairi et al. Cancer Genet. 2018 Jan.

Abstract

Colorectal cancer (CRC) is very heterogeneous and presents different types of epigenetic alterations including DNA methylation, histone modifications and microRNAs. These changes are considered as characteristics of various observed clinical phenotypes. Undoubtedly, the discovery of epigenetic pathways with novel epigenetic-related mechanisms constitutes a promising advance in cancer biomarker discovery. In this review, we provide an evidence-based discussing of the current understanding of CRC epigenomics and its role in initiation, epithelial-to-mesenchymal transition and metastasis. We also discuss the recent findings regarding the potential clinical perspectives of these alterations as potent biomarkers for CRC diagnosis, prognosis, and therapy in the era of liquid biopsy.

Keywords: Colorectal cancer; biomarkers; epigenetic; liquid biopsy; review.

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