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Review
. 2018 Feb;176(2):1085-1094.
doi: 10.1104/pp.17.01404. Epub 2018 Jan 8.

The SnRK1 Kinase as Central Mediator of Energy Signaling between Different Organelles

Bernhard Wurzinger  1 , Ella Nukarinen  1 , Thomas Nägele  1 , Wolfram Weckwerth  1   2 , Markus Teige  3
Affiliations
Review

The SnRK1 Kinase as Central Mediator of Energy Signaling between Different Organelles

Bernhard Wurzinger et al. Plant Physiol. 2018 Feb.

Abstract

SnRK1 is a central integrator of energy signaling in different subcellular locations with emerging roles in organellar and hormone metabolism.

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Figures

Figure 1.
Figure 1.
Different modes of metabolic regulation by SnRK1. SnRK1 regulates cytosolic metabolism directly by phosphorylation of metabolic enzymes and also can indirectly affect organellar metabolism via phosphorylation of TFs in the nucleus that regulate expression of nuclear-encoded organellar proteins. This, in turn, will affect the proteomic state within the organelles. The phosphorylation status of several plastid and mitochondria proteins is altered by yet unknown mechanisms in response to SnRK1 activity changes. TFs directly phosphorylated by SnRK1 are predicted to bind to nuclear-encoded plastid and mitochondria genes, eventually altering their transcription. The thereby altered metabolic state might be directly transduced into plastids and mitochondria, or indirectly via transcriptional regulation.
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