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. 2018 Jan 8;8(1):13.
doi: 10.1038/s41598-017-18467-8.

Correlative Factors of the Deterioration of Necrotizing Enterocolitis in Small for Gestational Age Newborns

Lijuan Luo  1 , Wenbin Dong  1 , Lingping Zhang  1 , Xuesong Zhai  1 , Qingping Li  1 , Xiaoping Lei  2
Affiliations

Correlative Factors of the Deterioration of Necrotizing Enterocolitis in Small for Gestational Age Newborns

Lijuan Luo et al. Sci Rep. .

Abstract

Small for gestational age (SGA) infants have an increased risk of necrotizing enterocolitis (NEC), but SGA has been found to not be a risk factor for the deterioration of NEC in previous literature. Few studies have focused on correlative factors of the progression of NEC in SGA newborns. The present retrospective observational study was performed in 64 SGA infants with Bell's stage II NEC. The dependent variable was Bell's stage II NEC that progressed to stage III after diagnosis. A stepwise forward multivariate logistic regression model was used to select potential correlative factors for the progression of NEC in SGA newborns. The results showed that elevation of CRP after NEC diagnosis (aOR 39.21, 95% CI 6.62-249.2) has an increased risk for deteriorating Bell's stage II NEC. In contrast, NEC in infants with congenital heart disease had a decreased risk of deterioration (aOR 0.11, 95% CI 0.01-0.92). Our findings indicated that serial CRP measurements post NEC diagnosis may be useful in predicting the deterioration of NEC.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow Chart in the Selection of SGA infants with Bell’s stage II NEC.
See this image and copyright information in PMC

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