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Review
. 2018 May;103(5):802-814.
doi: 10.1002/cpt.1010. Epub 2018 Feb 1.

Developing Drugs for Heart Failure With Reduced Ejection Fraction: What Have We Learned From Clinical Trials?

Markus Hinder  1 , B Alexander Yi  2 , Thomas H Langenickel  1
Affiliations
Review

Developing Drugs for Heart Failure With Reduced Ejection Fraction: What Have We Learned From Clinical Trials?

Markus Hinder et al. Clin Pharmacol Ther. 2018 May.

Abstract

There remains a large unmet need for new therapies in the treatment of heart failure with reduced ejection fraction (HFrEF). In the early drug development phase, the therapeutic potential of a drug is not yet fully understood and trial endpoints other than mortality are needed to guide drug development decisions. While a true surrogate marker for mortality in heart failure (HF) remains elusive, the successes and failures of previous trials can reveal markers that support clinical Go/NoGo decisions.

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Figures

Figure 1
Figure 1
An ideal case suggesting a Go decision.
Figure 2
Figure 2
A case suggesting a NoGo decision.
See this image and copyright information in PMC

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References

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