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. 2018 Mar 1;596(5):761-763.
doi: 10.1113/JP275582. Epub 2018 Jan 31.

Aerobic exercise promotes hippocampal neurogenesis through skeletal myofiber-derived vascular endothelial growth factor

I Vonderwalde  1 , A Kovacs-Litman  2
Affiliations

Aerobic exercise promotes hippocampal neurogenesis through skeletal myofiber-derived vascular endothelial growth factor

I Vonderwalde et al. J Physiol. .
No abstract available

Keywords: exercise; hippocampus; neurotrophic factor; plasticity; stem cells.

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Figures

Figure 1
Figure 1. Experimental paradigm used by Rich et al. (2017)
A, mutant male NES‐GFP/VEGF LoxP mice on a C57BL/6 background were divided into four groups based on ablation of VEGF and exposure to exercise training. B, the experimental schedule lasted 5 weeks. VEGF ablation was achieved within 3 weeks by tamoxifen administration for 5 days (day 0–4). The exercise phase lasted 2 weeks (day 21–36). BrdU labelling was conducted twice during the training phase to label proliferating NPCs. Mice were tested for maximal exercise performance on day 36 and killed by perfusion on day 37 to measure VEGF levels and NPC proliferation.
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