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Review
. 2018 Mar;25(3):220-227.
doi: 10.1111/jvh.12859.

Understanding and addressing hepatitis C reinfection in the oral direct-acting antiviral era

O Falade-Nwulia  1 , M S Sulkowski  1 , A Merkow  1 , C Latkin  2 , S H Mehta  2
Affiliations
Review

Understanding and addressing hepatitis C reinfection in the oral direct-acting antiviral era

O Falade-Nwulia et al. J Viral Hepat. 2018 Mar.

Abstract

The availability of effective, simple, well-tolerated oral direct-acting antiviral (DAA) hepatitis C regimens has raised optimism for hepatitis C virus (HCV) elimination at the population level. HCV reinfection in key populations such as people who inject drugs (PWID) and HIV-infected men who have sex with men (MSM) however threatens the achievement of this goal from a patient, provider and population perspective. The goal of this review was to synthesize our current understanding of estimated rates and factors associated with HCV reinfection. This review also proposes interventions to aid understanding of and reduce hepatitis C reinfection among PWID and HIV-infected MSM in the oral direct-acting antiviral era.

Keywords: hepatitis C; men who have sex with men; people who inject drugs; reinfection.

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Conflict of interest statement

Conflicts of interest

Dr. Sulkowski reports grants and personal fees from AbbVie, grants from BMS, personal fees from Cocrystal, grants and personal fees from Gilead, grants and personal fees from Janssen, grants and personal fees from Merck, personal fees from Trek, outside the submitted work.

Figures

Figure 1
Figure 1
HCV care continuum+: Preserving the benefits of HCV cure *PWID-People who inject drugs; NSP-Needle/syringe services program; OAT-Opioid agonist treatment; BI-behavioral intervention; MSM-Men who have sex with men; SBIRT-Screening, brief intervention, referral for treatment as needed
Figure 2
Figure 2
Algorithm for defining HCV reinfection in clinical practice A proposed clinical definition for HCV reinfection when the gold standard of phylogenetic analysis of pre- and post-treatment HCV sequences are not available
See this image and copyright information in PMC

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