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Comment
. 2018 Jan 8;28(1):R33-R36.
doi: 10.1016/j.cub.2017.11.025.

Immunology: The Neuronal Pathway to Mucosal Immunity

Stephan Löser  1 , Rick M Maizels  2
Affiliations
Free article
Comment

Immunology: The Neuronal Pathway to Mucosal Immunity

Stephan Löser et al. Curr Biol. .
Free article

Abstract

Type 2 immunity at mucosal surfaces is thought to be initiated by type 2 innate lymphoid cells. New studies report that these cells are themselves activated by the neuropeptide neuromedin U, produced by cholinergic neurons in the gut and in airways.

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  • The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.
    Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D. Klose CSN, et al. Nature. 2017 Sep 14;549(7671):282-286. doi: 10.1038/nature23676. Epub 2017 Sep 6. Nature. 2017. PMID: 28869965 Free PMC article.
  • Neuronal regulation of type 2 innate lymphoid cells via neuromedin U.
    Cardoso V, Chesné J, Ribeiro H, García-Cassani B, Carvalho T, Bouchery T, Shah K, Barbosa-Morais NL, Harris N, Veiga-Fernandes H. Cardoso V, et al. Nature. 2017 Sep 14;549(7671):277-281. doi: 10.1038/nature23469. Epub 2017 Sep 6. Nature. 2017. PMID: 28869974 Free PMC article.
  • The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.
    Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. Wallrapp A, et al. Nature. 2017 Sep 21;549(7672):351-356. doi: 10.1038/nature24029. Epub 2017 Sep 13. Nature. 2017. PMID: 28902842 Free PMC article.