Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Jan 8;44(1):1-2.
doi: 10.1016/j.devcel.2017.12.017. Epub 2018 Jan 8.

Understanding the Lipid Droplet Proteome and Protein Targeting

Joel M Goodman  1
Affiliations
Comment

Understanding the Lipid Droplet Proteome and Protein Targeting

Joel M Goodman. Dev Cell. .

Abstract

Reporting in this issue of Developmental Cell, Bersuker et al. (2018) adapt APEX technology to lipid droplets for a more accurate view of the droplet proteome and Prévost et al. (2018) provide important insights into the basis of droplet protein targeting that altogether extend the understanding of this organelle.

PubMed Disclaimer

Comment on

References

    1. Bersuker K, Peterson CWH, To M, Sahl SJ, Savikhin V, Grossman EA, Nomura DK, and Olzmann JA (2018). A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes. Dev. Cell 44, this issue, 97–112. - PMC - PubMed
    1. Brasaemle DL, Dolios G, Shapiro L, and Wang R (2004). Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J. Biol. Chem 279, 46835–46842. - PubMed
    1. Gao Q, and Goodman JM (2015). The lipid droplet-a well-connected organelle. Front. Cell Dev. Biol 3, 49. - PMC - PubMed
    1. Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, and Londos C (1991). Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem 266, 11341–11346. - PubMed
    1. Lam SS, Martell JD, Kamer KJ, Deerinck TJ, Ellisman MH, Mootha VK, and Ting AY (2015). Directed evolution of APEX2 for electron microscopy and proximity labeling. Nat. Methods 12, 51–54. - PMC - PubMed

LinkOut - more resources