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. 2018 Jan 9;11(1):13.
doi: 10.1186/s13104-017-3112-9.

Genome-wide diversity and runs of homozygosity in the "Braque Français, type Pyrénées" dog breed

Salvatore Mastrangelo  1 , Filippo Biscarini  2 , Barbara Auzino  3 , Marco Ragatzu  4 , Andrea Spaterna  5   6 , Roberta Ciampolini  6   3
Affiliations

Genome-wide diversity and runs of homozygosity in the "Braque Français, type Pyrénées" dog breed

Salvatore Mastrangelo et al. BMC Res Notes. .

Abstract

Objective: Braque Français, type Pyrénées is a French hunting-dog breed whose origin is traced back to old pointing gun-dogs used to assist hunters in finding and retrieving game. This breed is popular in France, but seldom seen elsewhere. Despite the ancient background, the literature on its genetic characterization is surprisingly scarce. A recent study looked into the demography and inbreeding using pedigree records, but there is yet no report on the use of molecular markers in this breed. The aim of this work was to genotype a population of Braque Français, type Pyrénées dogs with the high-density SNP array to study the genomic diversity of the breed.

Results: The average observed ([Formula: see text]) and expected ([Formula: see text]) heterozygosity were 0.371 ([Formula: see text]) and 0.359 ([Formula: see text]). Effective population size ([Formula: see text]) was 27.5635 runs of homozygosity (ROH) were identified with average length of 2.16 MB. A ROH shared by [Formula: see text] of the dogs was detected at the beginning of chromosome 22. Inbreeding coefficients from marker genotypes were in the range [Formula: see text]. Inbreeding estimated from ROH ([Formula: see text]) had mean [Formula: see text]), with range [0.0526, 0.225]. These results show that the Braque Français, type Pyrénées breed is a relatively inbred population, but with still sufficient genetic variability for conservation and genetic improvement.

Keywords: Braque Français, type Pyrénées; Dog; Genetic diversity; Heterozygosity; Inbreeding; Molecular markers; Runs of homozygosity; SNP.

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Figures

Fig. 1
Fig. 1
Manhattan plot of the proportion of times each SNP falls within a ROH in the analysed dog population
Fig. 2
Fig. 2
Runs of homozygosity (ROH) detected in each Braque Français, type Pyrénées dog on chromosome 22
See this image and copyright information in PMC

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