Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Feb 25:282:1-6.
doi: 10.1016/j.cbi.2018.01.002. Epub 2018 Jan 6.

Mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced cardiovascular toxicity: An overview

Mahdieh Sadat Mohsenzadeh  1 , Bamdad Riahi Zanjani  2 , Gholamreza Karimi  3
Affiliations
Review

Mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced cardiovascular toxicity: An overview

Mahdieh Sadat Mohsenzadeh et al. Chem Biol Interact. .

Abstract

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant and its toxicity is mediated by the aryl hydrocarbon receptor (AHR). Mechanisms of TCDD cardiovascular toxicity consist of oxidative stress, growth factor modulation, and ionic current alteration. It is indicated that the rodent cardiovascular system is a target for TCDD cardiomyopathy. Here, our understanding of TCDD cardiovascular toxicity is reviewed.

Keywords: Aryl hydrocarbon receptor; Cardiovascular dysfunction; Dioxin; TCDD.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources