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. 2018 Jan 9;8(1):138.
doi: 10.1038/s41598-017-18517-1.

Sex differences in risk factors of uncomplicated colonic diverticulosis in a metropolitan area from Northern China

Fang Yang  1   2 , Yanmin Zheng  1   2 , Xihui Jiang  1   2 , Zhengyan Su  1   2 , Ya Wang  1   2 , Lin Lin  1   2 , Houning Lv  1   2 , Jie Zhang  1   2 , Jingwen Zhao  1   2 , Bangmao Wang  1   2 , Kui Jiang  3   4 , Chao Sun  5   6
Affiliations

Sex differences in risk factors of uncomplicated colonic diverticulosis in a metropolitan area from Northern China

Fang Yang et al. Sci Rep. .

Abstract

As the world's most populated and rapidly aging country, there is limited information on sex-related differences in factors regarding uncomplicated colonic diverticulosis in China. We aimed to investigate sex differences in individual risk factor in a northern metropolis. Patients with colonic diverticulosis who underwent indicated colonoscopy were queried with respect to medical history and demographic features. Demographic information, life style factors and co-morbidities were retrieved from a prospective dataset. Multiple regression analyses were performed to determine precipitating factors of diverticula. Of 4,386 enrolled patients, colonic diverticulosis were detected in 218 cases (4.97%). Multiple logistic regression analysis implicated increasing age (OR = 1.05, 95%CI 1.03-1.06, P < 0.001), red meat ≥100 g/d (OR = 2.53, 95%CI 1.72-3.70, P < 0.001), smoking (OR = 2.14, 95%CI 1.05-4.33, P = 0.035), rheumatologic diseases (OR = 3.38, 95%CI 1.09-10.5, P = 0.035) and NSAIDs (OR = 2.11, 95%CI 1.12-3.97, P = 0.020) were significantly associated with diverticulosis in men, whilst advancing age (OR = 1.03, 95%CI 1.01-1.05, P = 0.013), BMI (OR = 1.12, 95%CI 1.04-1.19, P = 0.001), smoking (OR = 10.2, 95%CI 2.81-37.4, P < 0.001), rheumatologic diseases (OR = 8.04, 95%CI 3.05-21.2, P < 0.001), hypertension (OR = 1.76, 95%CI 1.01-3.06, P = 0.047), colonic polyps (OR = 3.12, 95%CI 1.82-5.36, P < 0.001) and antihypertensive medications (OR = 2.99, 95%CI 1.66-5.39, P < 0.001) in women. In conclusion, it is pivotal to take account of differentially sex-related factors in regard to the development of uncomplicated colonic diverticulosis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of patients included for current study.
Figure 2
Figure 2
Proportion of subjects with indicated risk factor (P < 0.05 for all) and odds ratio (OR) relative to reference in study population by the presence of diverticula. Circles show the proportion (y-axis) and OR (diameter) relative to each reference. Div (+), patients with diverticulosis; Div (−), patients without diverticulosis.
See this image and copyright information in PMC

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