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. 2017 Dec 22:11:83-95.
doi: 10.2147/OTT.S142847. eCollection 2018.

Prognosis of patients with primary malignant main stem bronchial tumors: 7,418 cases based on the SEER database

Ke Ma #  1 , Fenghao Sun #  1 , Xiaodong Yang  1 , Shuai Wang  1 , Lin Wang  1 , Yulin Jin  1 , Yu Shi  1 , Wei Jiang  1 , Cheng Zhan  1 , Qun Wang  1
Affiliations

Prognosis of patients with primary malignant main stem bronchial tumors: 7,418 cases based on the SEER database

Ke Ma et al. Onco Targets Ther. .

Abstract

Background: The aim of this study was to identify risk factors for patients with malignant main stem bronchial tumors (MBTs) and to develop a nomogram for predicting prognosis in those patients using data from the Surveillance, Epidemiology, and End Results (SEER) database.

Method: A process was used for case screening from the SEER database. The effect of prognostic factors on survival was evaluated using the Kaplan-Meier method and log-rank test, a competing risk model, and the Cox proportional hazards regression model. A nomogram was established for predicting 1-, 3-, and 5-year overall survival (OS) in patients with MBTs.

Results: A total of 7,418 cases were included in this study. Age, gender, pathologic grade, histologic type, tumor size, involvement of lymph nodes, tumor extension, chemotherapy, and surgery were identified as independent risk factors by univariate and multivariate analyses. A nomogram was established based on the results of the Cox model, which was validated by a C-index of 0.672 (95% CI, 0.664-0.680), and a group of calibration plots.

Conclusion: Age, gender, pathologic grade, histologic type, tumor size, involvement of lymph nodes, tumor extension, chemotherapy, and surgery were independent risk factors for OS of patients with MBTs. A nomogram was formulated to predict 1-, 3-, and 5-year OS in patients with MBTs based on individual clinical characteristics.

Keywords: malignant main stem bronchial tumor; nomogram; prognosis; risk factors.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The flow diagram of the selection process for the study. Abbreviation: MBTs, malignant main stem bronchial tumors.
Figure 2
Figure 2
Overall Kaplan–Meier survival curve of all included patients.
Figure 3
Figure 3
Overall Kaplan–Meier survival curve for patients according to (A) age, (B) gender, and (C) race.
Figure 4
Figure 4
Overall Kaplan–Meier survival curve for patients according to (A) histologic type, (B) pathologic grade, (C) tumor size, (D) involvement of lymph node, and (E) tumor extension. Abbreviations: SQCC, squamous cell carcinoma; AC, adenocarcinoma; LCC, large-cell carcinoma; SMCC, small-cell carcinoma.
Figure 5
Figure 5
Overall Kaplan–Meier survival curve for patients according to (A) surgery, (B) chemotherapy, and (C) radiotherapy.
Figure 6
Figure 6
A nomogram for prediction of 1-, 3-, and 5-year OS rates of patients with MBTs. Abbreviations: OS, overall survival; MBTs, malignant main stem bronchial tumors; SQCC, squamous cell carcinoma; AC, adenocarcinoma; LCC, large cell carcinoma; SMCC, small cell carcinoma;.
Figure 7
Figure 7
Calibration curve of the nomogram predicting (A) 1-year, (B) 3-year, and (C) 5-year OS rates of patients with MBTs. Abbreviations: OS, overall survival; MBTs, malignant main stem bronchial tumors.
See this image and copyright information in PMC

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