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. 2017 Dec 14:12:450-467.
doi: 10.1515/med-2017-0064. eCollection 2017.

HIV/STI Prevention Interventions: A Systematic Review and Meta-analysis

Jason Globerman  1 , Sanjana Mitra  1 , David Gogolishvili  1 , Sergio Rueda  2 , Laura Schoffel  1 , Kira Gangbar  1 , Qiyun Shi  1 , Sean B Rourke  3
Affiliations

HIV/STI Prevention Interventions: A Systematic Review and Meta-analysis

Jason Globerman et al. Open Med (Wars). .

Abstract

Behavioral interventions can prevent the transmission of HIV and sexually transmitted infections. This systematic review and meta-analysis assesses the effectiveness and quality of available evidence of HIV prevention interventions for people living with HIV in high-income settings. Searches were conducted in MEDLINE, EMBASE, PsycINFO, and CDC Compendium of Effective Interventions. Interventions published between January, 1998 and September, 2015 were included. Quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Forty-six articles and 63 datasets involving 14,096 individuals met inclusion criteria. Included articles were grouped by intervention type, comparison group and outcome. Few of these had high or moderate quality of evidence and statistically significant effects. One intervention type, group-level health education interventions, were effective in reducing HIV/STI incidence when compared to attention controls. A second intervention type, comprehensive risk counseling and services, was effective in reducing sexual risk behaviors when compared to both active and attention controls. All other intervention types showed no statistically significant effect or had low or very low quality of evidence. Given that the majority of interventions produced low or very low quality of evidence, researchers should commit to rigorous evaluation and high quality reporting of HIV intervention studies.

Keywords: HIV; intervention, risk behavior; prevention; sexually transmitted infections.

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Conflict of interest statement

Conflict of interest: Authors state no conflict of interest. The authors received no specific funding for this work.

Figures

Figure 1
Figure 1
Flow chart of study selection process
See this image and copyright information in PMC

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