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Case Reports
. 2016 Nov 9;2(3):493-497.
doi: 10.1016/j.ekir.2016.11.002. eCollection 2017 May.

Extreme Renal Pathology in Alagille Syndrome

Mei Lin Z Bissonnette  1 , Jerome C Lane  2 , Anthony Chang  3
Affiliations
Case Reports

Extreme Renal Pathology in Alagille Syndrome

Mei Lin Z Bissonnette et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Glomerular basement membranes show a prominent vacuolated appearance and focal subepithelial “spike” formation, which appears identical to membranous nephropathy (Jones methenamine silver, original magnification ×600).
Figure 2
Figure 2
Several immature tubules and a large bile cast is present on the left (hematoxylin and eosin, original magnification ×40).
Figure 3
Figure 3
Numerous lipid vacuoles with characteristic electron dense and lucent areas are embedded in the glomerular basement membranes and some mesangial cells. Some of the lipid vacuoles are subepithelial, intramembranous, or subendothelial in location (bar = 2 μm).
Figure 4
Figure 4
Similar lipid vacuoles also accumulate within the tubular basement membranes (original magnification ×5000).
See this image and copyright information in PMC

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