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. 1985 Aug;72(2):140-4.
doi: 10.1111/j.1600-0404.1985.tb00855.x.

Abnormalities of T-lymphocyte subsets in epileptic patients

O Eeg-Olofsson, J F Prchal, F Andermann

Abnormalities of T-lymphocyte subsets in epileptic patients

O Eeg-Olofsson et al. Acta Neurol Scand. 1985 Aug.

Abstract

This study concerns the distribution of T-cell subsets as determined by specific monoclonal antibodies in 50 individuals with complex partial seizures (31) and primary generalized tonic-clonic seizures (19), and in 30 healthy controls. The epileptic group had significantly fewer circulating T4 "helper" lymphocytes and significantly greater number of T8 "suppressor" lymphocytes than the controls. The T4/T8 ratio was consistently significantly lower in the epileptic group. There was no relation between lymphocyte subsets or T4/T8 ratio and antiepileptic medication. The results suggest a derangement of cell-mediated immunity in individuals with epilepsy.

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