. 2019 Mar;25(3):344-351.

doi: 10.1177/1352458517750768. Epub 2018 Jan 11.

Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients

Affiliations

¹ Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA/ Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA/Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA/Massachusetts General Hospital's Biostatistics Center, Boston, MA, USA.
³ Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
⁴ Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Harvard Medical School, Boston, MA, USA/Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁶ Harvard Medical School, Boston, MA, USA/Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.

PMID: 29320952
PMCID: PMC6026579
DOI: 10.1177/1352458517750768

Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients

Riley Bove et al. Mult Scler. 2019 Mar.

. 2019 Mar;25(3):344-351.

doi: 10.1177/1352458517750768. Epub 2018 Jan 11.

Authors

Affiliations

¹ Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA/ Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
² Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA/Harvard Medical School, Boston, MA, USA/Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA/Massachusetts General Hospital's Biostatistics Center, Boston, MA, USA.
³ Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
⁴ Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Harvard Medical School, Boston, MA, USA/Ann Romney Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁶ Harvard Medical School, Boston, MA, USA/Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.

PMID: 29320952
PMCID: PMC6026579
DOI: 10.1177/1352458517750768

Abstract

Background: Increased adiposity is a risk factor for multiple sclerosis (MS) and is associated with increased disability scores. Adipokines may mediate the effects of adiposity on MS disease course.

Objective: The objective of this study is to examine the association between the adipokines (leptin and fatty acid binding protein-4, FABP4) and clinical course in individuals with MS.

Methods: Subjects (18-65 years) with relapsing-remitting MS or clinically isolated syndrome and <10 year disease duration were selected from a longitudinal clinical study. Cross-sectional and longitudinal models assessed the relationship between two adipokines (leptin and FABP4) and disease severity in women and men, adjusting for age, disease duration and disease type, Vitamin D level, testosterone level, and as well by body mass index (BMI).

Results: Mean age of subjects ( N = 163, 56% women) was 39.3 years. Higher FABP4 levels were associated with higher Expanded Disability Status Scale (EDSS) scores in women in both univariate and multivariate analyses (odds ratio: 1.30; p = 0.005). In men, higher FABP4 level was significantly associated with change in EDSS over time (estimate: 0.0062; p = 0.035). We found no association of FABP4 levels with time to next relapse or a measure of processing speed.

Conclusion: FABP4 levels may be associated with increased disability in both men and women with MS independent of effects of BMI and other hormones. Future studies should expand these analyses and further explore downstream mechanisms of adiposity-related effects in MS.

Keywords: Body mass index; fatty acid binding protein; gender; leptin; multiple sclerosis.

PubMed Disclaimer

Conflict of interest statement

DECLARATION OF CONFLICTING INTERESTS

Conflict of interest statement: None declared

Dr. Bove reports no disclosures

Dr. Brian Healy has received research support from Merck Serono and Novartis Alexander Musallam reports no disclosures

Dr. Pejvak Soltany reports no disclosures

Dr. Bonnie I Glanz has received research support from Merck-Serono.

Dr. Pia Kivisakk has received research support from Merck-Serono

Dr. Karen Klahr Miller reports no disclosures.

Dr. Tanuja Chitnis has served as a consultant for Biogen-Idec, Teva Neurosciences, Novartis, Sanofi-Aventis, and has received grant support from Merck-Serono and Novartis.

References

1. Munger KL, Chitnis T, Ascherio A. Body size and risk of MS in two cohorts of US women. Neurology. 2009;73:1543–50. - PMC - PubMed
1. Hedstrom AK, Olsson T, Alfredsson L. High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler. 2012;18:1334–6. - PubMed
1. Munger KL, Bentzen J, Laursen B, et al. Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Mult Scler. 2013;19:1323–9. - PMC - PubMed
1. Hedstrom AK, Lima Bomfim I, Barcellos L, et al. Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology. 2014 - PMC - PubMed
1. Langer-Gould A, Brara SM, Beaber BE, Koebnick C. Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome. Neurology. 2013;80:548–52. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients

Affiliations

Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials

Miscellaneous