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Review
. 2018 Feb;236(2):R105-R108.
doi: 10.1530/JOE-17-0542.

Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate

Affiliations
Review

Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate

Filipe de Vadder et al. J Endocrinol. 2018 Feb.

Abstract

In the context of the obesity epidemic, dietary fibers that are found essentially in fruit and vegetables attract more and more attention, since they exert numerous metabolic benefits resulting in the moderation of body weight. Short-chain fatty acids, such as propionate and butyrate, produced through their fermentation by the intestinal microbiota, have long been thought to be the mediators of these benefits. In fact, propionate and butyrate were recently shown to activate intestinal gluconeogenesis, a function exerting metabolic benefits via its capacity of signaling to the brain by gastrointestinal nerves. Recently, succinate, the precursor of propionate in the bacterial metabolism, has also been shown to exert signaling properties, including the activation of intestinal gluconeogenesis.

Keywords: glucose metabolism; gut microbiota; gut–brain axis; intestinal gluconeogenesis; short-chain fatty acid; succinate.

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