Identification of new α-synuclein regulator by nontraditional drug development pipeline

Xi Chen¹, Sonja W Scholz^{2

3}

Affiliations

¹ Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
² Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
³ Department of Neurology, Johns Hopkins University Medical Center, Baltimore, Maryland, USA.

Comment

Xi Chen et al. Mov Disord. 2018 Mar.

. 2018 Mar;33(3):402.

doi: 10.1002/mds.27278. Epub 2018 Jan 11.

Xi Chen¹, Sonja W Scholz^{2

3}

¹ Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
² Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
³ Department of Neurology, Johns Hopkins University Medical Center, Baltimore, Maryland, USA.

No abstract available

Comment on

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.
Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. Mittal S, et al. Science. 2017 Sep 1;357(6354):891-898. doi: 10.1126/science.aaf3934. Science. 2017. PMID: 28860381 Free PMC article.

1. Singleton AB, Farrer M, Johnson J, et al. alpha-Synuclein locus triplication causes Parkinson’s disease. Science. 2003;302(5646):841. - PubMed
1. Fuchs J, Nilsson C, Kachergus J, et al. Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. Neurology. 2007;68(12):916–922. - PubMed
1. Miller DW, Hague SM, Clarimon J, et al. Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology. 2004;62(10):1835–1838. - PubMed
1. Mittal S, Bjornevik K, Im DS, et al. beta2-Adrenoreceptor is a regulator of the alpha-synuclein gene driving risk of Parkinson’s disease. Science. 2017;357(6354):891–898. - PMC - PubMed