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Review
. 2019 Jul;10(3):321-328.
doi: 10.1177/1947603517749921. Epub 2018 Jan 11.

Mechanical, Cellular, and Proteomic Properties of Laryngotracheal Cartilage

Christine M Pauken  1 , Richard Heyes  1 , David G Lott  1
Affiliations
Review

Mechanical, Cellular, and Proteomic Properties of Laryngotracheal Cartilage

Christine M Pauken et al. Cartilage. 2019 Jul.

Abstract

The larynx sometimes requires repair and reconstruction due to cancer resection, trauma, stenosis, or developmental disruptions. Bioengineering has provided some scaffolding materials and initial attempts at tissue engineering, especially of the trachea, have been made. The critical issues of providing protection, maintaining a patent airway, and controlling swallowing and phonation, require that the regenerated laryngotracheal cartilages must have mechanical and material properties that closely mimic native tissue. These properties are determined by the cellular and proteomic characteristics of these tissues. However, little is known of these properties for these specific cartilages. This review considers what is known and what issues need to be addressed.

Keywords: arytenoid; cartilage; corniculate; cricoid; cuneiform; epiglottic; larynx; proteomic; regenerative medicine; thyroid; tissue engineering; trachea.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Picosirius red staining of the thyroid cartilage of a young male.
Figure 2.
Figure 2.
Section of cricoid cartilage stained with (A) hematoxylin and eosin or (B) picosirius red to show the intense staining of the collagen.
See this image and copyright information in PMC

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