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Editorial
. 2018;17(2):137-138.
doi: 10.1080/15384101.2017.1360637. Epub 2018 Jan 18.

RNF8 - The Achilles heel of DNA repair when splicing rules

Affiliations
Editorial

RNF8 - The Achilles heel of DNA repair when splicing rules

Chiara Pederiva et al. Cell Cycle. 2018.
No abstract available

Keywords: DNA double-strand break repair; RNF8; ionizing radiation; spliceosome; splicing inhibition.

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Figures

Figure 1.
Figure 1.
Model of splicing-regulated repair of DNA double-strand breaks.

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References

    1. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ.. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007;316:1160-66. doi:10.1126/science.1140321. PMID:17525332. - DOI - PubMed
    1. Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA.. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell. 2009;35:228-39. doi:10.1016/j.molcel.2009.06.021. PMID:19647519. - DOI - PMC - PubMed
    1. Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol. 2012;14:318-28. doi:10.1038/ncb2426. PMID:22344029. - DOI - PMC - PubMed
    1. Herr P, Lundin C, Evers B, Ebner D, Bauerschmidt C, Kingham G, Palmai-Pallag T, Mortusewicz O, Frings O, Sonnhammer E, Helleday T.. A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discov. 2015;1:15034. doi:10.1038/celldisc.2015.34. PMID:27462432. - DOI - PMC - PubMed
    1. Pederiva C, Bohm S, Julner A, Farnebo M. Splicing controls the ubiquitin response during DNA double-strand break repair. Cell Death Differ. 2016;28(24):2726–38. doi:10.1038/cdd.2016.58. PMID:27315300. - DOI - PMC - PubMed

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