Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Published Erratum
. 2009 Nov;69(21):8526-8527.
doi: 10.1158/0008-5472.CAN-09-3534. Epub 2009 Oct 20.

Correction: Development and Cancer: At the Crossroads of Nodal and Notch Signaling

No authors listed
Published Erratum

Correction: Development and Cancer: At the Crossroads of Nodal and Notch Signaling

No authors listed. Cancer Res. 2009 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Convergence of Nodal and Notch signaling. A, Nodal can bind to ALK4/7 and ActRIIB receptors and induce smad-2/3/4-dependent signaling in a Cripto-1 dependent or independent manner, leading to activation of target genes including FoxH1, Nodal, and Lefty. Binding of Notch receptors to ligands expressed on adjacent cells leads to enzymatic cleavage by gamma-secretase (g-SC) and intracytoplasmic release of the active NICD. The CSL DNA binding protein can function as a transcriptional repressor. However, when NCID binds to CSL, it forms an activator complex leading to target gene transcription. Cripto-1 may also play a role in regulating Notch expression in melanoma cells (broken arrows). B, during the establishment of left-right asymmetry in mouse, Nodal expression around the node (ND) is directly regulated by Notch/Delta-like-1 (DLL1) signaling. This domain of Nodal expression is required for the subsequent expression of Nodal in the left lateral plate mesoderm (LLPM), which autoregulates its own expression, as well as the expression of Lefty2 in the LLPM and Lefty1 in the left presumptive floor plate. Together these proteins function to restrict Nodal signaling to the left side of the embryo where it induces left-sided structures. The Nodal coreceptor, CFC1 (Cryptic), an ortholog of human Cripto-1, is symmetrically expressed in both the left and right lateral plate mesoderm (RLPM), as well as in the node and along the left midline. Thin arrows indicate regulation at the transcriptional level. Block symbols indicate regulation at the protein level. Abbreviations: ND, node; NT, notochord, PS, primitive streak; LLPM, left lateral plate mesoderm; RLPM, right lateral plate mesoderm. C, human embryonic stem cell-conditioned matrix (hESCMTX) contains factors, such as Lefty, capable of repressing Nodal expression in aggressive human melanoma cells (C8161). These cells also show increased miR-302a levels that could inhibit Notch signaling and Nodal expression. Inhibition of Nodal signaling may lead to redifferentiation or apoptosis in C8161 cells.
See this image and copyright information in PMC

Erratum for

References

    1. Strizzi L, Hardy KM, Seftor EA, Costa FF, Kirschmann DA, Seftor REB, Postovit L-M, Hendrix MJC. Development and cancer: at the crossroads of Nodal and Notch signaling. Cancer Res. 2009;69:7131–4. - PMC - PubMed

Publication types