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Comment
. 2018 Jan 10;23(1):3-4.
doi: 10.1016/j.chom.2017.12.012.

LACTATEing Salmonella: A Host-Derived Fermentation Product Fuels Pathogen Growth

Bärbel Stecher  1 , Kirsten Jung  2
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LACTATEing Salmonella: A Host-Derived Fermentation Product Fuels Pathogen Growth

Bärbel Stecher et al. Cell Host Microbe. .
Free article

Abstract

Infection by Salmonella enterica serovar Typhimurium is accompanied by dysbiosis and a decrease of microbiota-derived butyrate. In this issue of Cell Host & Microbe, Gillis et al. (2018) demonstrate that the lack of butyrate reprograms colonic epithelial metabolism toward lactate fermentation. Lactate is then used as a respiratory electron donor, supporting Salmonella growth and thus promoting infection.

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