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Comment
. 2018 Jan 12;359(6372):163-164.
doi: 10.1126/science.aar5541.

Silencing stemness in T cell differentiation

Amanda N Henning  1   2 , Christopher A Klebanoff  3   4 , Nicholas P Restifo  5   2
Affiliations
Comment

Silencing stemness in T cell differentiation

Amanda N Henning et al. Science. .
No abstract available

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Figures

Figure.
Figure.. Shutting down stem and memory genes in CD8+ T cells
As cells differentiate, stem and memory genes pass through transitional epigenetic states, in which epigenetic modifications associated with transcriptional activation, including H3K4me3 and H3K27ac, are lost via lysine demethylases (KDMs) and histone deacetylases (HDACs). Conversely, repressive modifications such as DNA methylation, H3K27me3, and H3K9me3 are gained because of epigenetic writers, including DNMT3A, EZH2 as part of the Polycomb repressive complex 2 (PRC2), and SUV39H1. Not shown but occurring simultaneously is the acquisition of activating epigenetic modifications at effector-associated genes during T cell differentiation.
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References

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