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Case Reports
. 2018 Jan 4:23:20-23.
doi: 10.1016/j.gore.2018.01.002. eCollection 2018 Feb.

Aggressive neuroendocrine tumor of the ovary with multiple metastases treated with everolimus: A case report

Michiko Kaiho-Sakuma  1 , Masafumi Toyoshima  1 , Mika Watanabe  2 , Asami Toki  1 , Satomi Kameda  1 , Takamichi Minato  1 , Hitoshi Niikura  1 , Nobuo Yaegashi  1
Affiliations
Case Reports

Aggressive neuroendocrine tumor of the ovary with multiple metastases treated with everolimus: A case report

Michiko Kaiho-Sakuma et al. Gynecol Oncol Rep. .

Abstract

•Neuroendocrine tumors (NETs) frequently occur in the lungs or the gastrointestinal tract; they are uncommon in the ovary.•The mammalian target of rapamycin (mTOR) pathway has been reported as a treatment for advanced NETs.•We describe a patient with an aggressive primary ovarian NET, successfully treated with everolimus (an mTOR inhibitor).

Keywords: BEP, bleomycin, etoposide, and cisplatin; CA-125, carbohydrate antigen 125; CD56, cluster of differentiation 56; CDX2, caudal-type homeobox transcription factor 2; CT, computed tomography; Carcinoid; EMA, epithelial membrane antigen; Everolimus; FIGO, International Federation of Gynecology and Obstetrics; MRI, magnetic resonance imaging; Multiple metastases; NETs, neuroendocrine tumors; Neuroendocrine tumor; Ovary; mTOR, mammalian target of rapamycin.

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Figures

Fig. 1
Fig. 1
Imaging studies. (A) T2-weighted magnetic resonance imaging (MRI), sagittal section. (B) T1-weighted, enhanced MRI, horizontal section. (C) Computed tomography (CT) showing metastasis to the liver; (D) CT showing metastasis to the right kidney.
Fig. 2
Fig. 2
Pathological findings. (A) Gross appearance of the resected ovarian tumor shows a 20-cm, solid mass with an irregular, smooth surface. (B) The cut surface shows fleshy, tan-yellow, heterogeneous tissue with focal hemorrhage, necrosis, and cystic change. (C) Hematoxylin and eosin staining. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Fig. 3
Fig. 3
Immunohistochemistry. The tumor cells are strongly positive for (A) synaptophysin and (B) chromogranin A. (C) The tumor cells are negative for inhibinα. (D) The Ki-67 index is 17%.
See this image and copyright information in PMC

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