Weaving New Insights for the Genetic Regulation of Human Cognitive Phenotypes
- PMID: 29328907
- DOI: 10.1016/j.cell.2017.12.037
Weaving New Insights for the Genetic Regulation of Human Cognitive Phenotypes
Abstract
Psychiatric genetic studies have drawn associations between human cognitive traits and noncoding genomic variants. However, the mechanistic effects of these variants are unclear. By weaving in strands of genomic data from developing human brains, de la Torre-Ubieta et al. tie disease-associated loci to functional enhancers, target genes, and putatively affected cell types.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.Cell. 2018 Jan 11;172(1-2):289-304.e18. doi: 10.1016/j.cell.2017.12.014. Epub 2018 Jan 4. Cell. 2018. PMID: 29307494 Free PMC article.
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