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Comment
. 2018 Jan 11;172(1-2):8-10.
doi: 10.1016/j.cell.2017.12.029.

A Viral (Arc)hive for Metazoan Memory

Nicholas F Parrish  1 , Keizo Tomonaga  2
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A Viral (Arc)hive for Metazoan Memory

Nicholas F Parrish et al. Cell. .
Free article

Abstract

Arc, a master regulator of synaptic plasticity, contains sequence elements that are evolutionarily related to retrotransposon Gag genes. Two related papers in this issue of Cell show that Arc retains retroviral-like capsid-forming ability and can transmit mRNA between cells in the nervous system, a process that may be important for synaptic function.

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