Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Apr;18(4):361-363.
doi: 10.1016/S1473-3099(18)30003-3. Epub 2018 Jan 9.

Herd immunity: hyperimmune globulins for the 21st century

Affiliations
Comment

Herd immunity: hyperimmune globulins for the 21st century

Sarah Tc Elliott et al. Lancet Infect Dis. 2018 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
SAB-301 production in transchromosomic cattle MERS=Middle East respiratory syndrome. HAC=human artificial chromosome. IGM=immunoglobulin heavy constant μ. IGHG1=immunoglobulin heavy constant gamma 1.
None

Comment on

References

    1. Marano G, Vaglio S, Pupella S. Convalescent plasma: new evidence for an old therapeutic tool? Blood Transfus. 2016;14:152–157. - PMC - PubMed
    1. Arabi YM, Hajeer AH, Luke T. Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia. Emerg Infect Dis. 2016;22:1554–1561. - PMC - PubMed
    1. Beigel JH, Voell J, Kumar P. Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody: a phase 1 randomised, double-blind, single-dose-escalation study. Lancet Infect Dis. 2018 doi: 10.1016/S1473-3099(18)30002-1. published online Jan 9. - DOI - PMC - PubMed
    1. Kuroiwa Y, Kasinathan P, Sathiyaseelan T. Antigen-specific human polyclonal antibodies from hyperimmunized cattle. Nat Biotechnol. 2009;27:173–181. - PubMed
    1. Bounds CE, Kwilas SA, Kuehne AI. Human polyclonal antibodies produced through dna vaccination of transchromosomal cattle provide mice with post-exposure protection against lethal Zaire and Sudan Ebolaviruses. PLoS One. 2015;10:e0137786. - PMC - PubMed

LinkOut - more resources