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Clinical Trial
. 2018 Jan 12;8(1):619.
doi: 10.1038/s41598-017-19113-z.

Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

Eliana Rulli  1 , Luciano Quaranta  2 , Ivano Riva  3 , Davide Poli  1 , Lital Hollander  1 , Fabio Galli  1 , Andreas Katsanos  4 , Francesco Oddone  3 , Valter Torri  1 , Robert N Weinreb  5 ; Italian Study Group on QoL in Glaucoma
Collaborators, Affiliations
Clinical Trial

Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

Eliana Rulli et al. Sci Rep. .

Erratum in

Abstract

The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or "glaucoma suspect" patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were classified as having VF damage in one eye (VFD-1), both eyes (VFD-2), or neither eye (VFD-0). 3227 patients were enrolled and 2940 were eligible for the analysis. 13.4% of patients were classified in the VFD-0, 23.7% in the VFD-1, and 62.9% in the VFD-2 group. GSS visual symptoms domain (Func-4) and GSS non-visual symptoms domain (Symp-6) scores were similar for the VFD-0 and VFD-1 groups (p = 0.133 and p = 0.834 for Func-4 and Symp-6, respectively). VFD-0 group had higher scores than VFD-2 both in Func-4 (p < 0.001) and Symp-6 domains (p = 0.035). Regarding the NEI-VFQ-25, our data demonstrated that bilateral VF defects are associated with vision-related QoL deterioration, irrespective of visual acuity.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Visual field stages according to Glaucoma Staging System 2: simulation of what patients see at different stages. On the left Glaucoma Staging System 2 diagrams, in the middle visual field gray scale, on the right simulation of what patients see.
Figure 2
Figure 2
Glaucoma Symptom Scale (GSS) questionnaire scores depending on the presence of glaucoma and visual field damage (eye as unit of analysis).
Figure 3
Figure 3
Glaucoma Symptom Scale (GSS) questionnaire scores by stage according to Glaucoma Staging System 2 (eye as unit of analysis).
See this image and copyright information in PMC

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