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Meta-Analysis
. 2018 Feb;109(2):356-364.e32.
doi: 10.1016/j.fertnstert.2017.10.018. Epub 2018 Jan 11.

Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Bulent Yilmaz  1 , Priyathama Vellanki  2 , Baris Ata  3 , Bulent Okan Yildiz  4
Affiliations
Meta-Analysis

Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Bulent Yilmaz et al. Fertil Steril. 2018 Feb.

Abstract

Objective: To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS).

Design: Systematic review and meta-analysis.

Setting: Not applicable.

Patient(s): Mothers, fathers, sisters, and brothers of women with and without PCOS.

Intervention(s): An electronic-based search with the use of PubMed from 1960 to June 2015 and cross-checked references of relevant articles.

Main outcome measure(s): Metabolic syndrome, hypertension and dyslipidemia, and surrogate markers, including systolic blood pressure (BP), diastolic BP, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides.

Result(s): Fourteen of 3,346 studies were included in the meta-analysis. Prevalence of the following was significantly increased in relatives of women with PCOS: metabolic syndrome (risk ratio [RR] 1.78 [95% confidence interval 1.37, 2.30] in mothers, 1.43 [1.12, 1.81] in fathers, and 1.50 [1.12, 2.00] in sisters), hypertension (RR 1.93 [1.58, 2.35] in fathers, 2.92 [1.92, 4.45] in sisters), and dyslipidemia (RR 3.86 [2.54, 5.85] in brothers and 1.29 [1.11, 1.50] in fathers). Moreover, systolic BP (mothers, sisters, and brothers), total cholesterol (mothers and sisters), low-density lipoprotein cholesterol (sisters), and triglycerides (mothers and sisters) were significantly higher in first-degree relatives of PCOS probands than in controls.

Conclusion(s): Our results show evidence of clustering for metabolic syndrome, hypertension, and dyslipidemia in mothers, fathers, sisters, and brothers of women with PCOS.

Systematic review registration number: PROSPERO 2016 CRD42016048557.

Keywords: Dyslipidemia; first-degree relatives; hypertension; metabolic syndrome; polycystic ovary syndrome.

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Figures

FIGURE 1
FIGURE 1
Flow chart of study selection for systematic review and meta-analysis.
FIGURE 2
FIGURE 2
Forest plot of MetS prevalence in PCOS mothers (A), fathers (B), sisters (C), and brothers (D) vs. controls. “Dunaif and Legro” includes data from 10 studies (references 14–19, 68–71). M–H = Mantel–Haenszel.
See this image and copyright information in PMC

Comment in

  • Family Ties.
    Laven JSE. Laven JSE. Fertil Steril. 2018 Feb;109(2):254-255. doi: 10.1016/j.fertnstert.2017.11.024. Epub 2018 Jan 6. Fertil Steril. 2018. PMID: 29317128 No abstract available.

References

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