Guidelines of care for the management of cutaneous squamous cell carcinoma

doi:10.1016/j.jaad.2017.10.007

Practice Guideline

. 2018 Mar;78(3):560-578.

doi: 10.1016/j.jaad.2017.10.007. Epub 2018 Jan 10.

Guidelines of care for the management of cutaneous squamous cell carcinoma

Work Group; Invited Reviewers; John Y S Kim¹, Jeffrey H Kozlow², Bharat Mittal³, Jeffrey Moyer⁴, Thomas Olenecki⁵, Phillip Rodgers⁶

Collaborators, Affiliations

Collaborators

Murad Alam⁷, April Armstrong⁸, Christian Baum⁹, Jeremy S Bordeaux¹⁰, Marc Brown¹¹, Klaus J Busam¹², Daniel B Eisen¹³, Vivek Iyengar¹⁴, Clifford Lober¹⁵, David J Margolis¹⁶, Jane Messina¹⁷, Alexander Miller¹⁸, Stanley Miller¹⁹, Eliot Mostow²⁰, Christen Mowad²¹, Kishwer Nehal²², Kristi Schmitt-Burr²³, Aleksandar Sekulic²⁴, Paul Storrs¹⁴, Joyce Teng²⁵, Siegrid Yu²⁶, Conway Huang²⁷, Kevin Boyer²⁸, Wendy Smith Begolka²⁹, Christopher Bichakjian³⁰

Affiliations

¹ Department of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois.
² Section of Plastic and Reconstructive Surgery, University of Michigan, Ann Arbor, Michigan.
³ Department of Radiation Oncology, Northwestern University, Chicago, Illinois.
⁴ Department of Otolaryngology, Plastic/Head/Neck Surgery, University of Michigan, Ann Arbor, Michigan.
⁵ Department of Internal Medicine, Ohio State University, Columbus, Ohio.
⁶ Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.
⁷ Department of Dermatology, Northwestern University, Chicago, Illinois.
⁸ Department of Dermatology, University of Colorado, Denver, Colorado.
⁹ Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
¹⁰ Case Western Reserve University School of Medicine, Cleveland, Ohio.
¹¹ Department of Dermatology, University of Rochester, Rochester, Minnesota.
¹² Dermatopathology, Memorial Sloan-Kettering, New York, New York.
¹³ Department of Dermatology, University of California Davis, Sacramento, California.
¹⁴ Private practice, Chicago, Illinois.
¹⁵ Private practice, Kissimmee, Florida.
¹⁶ University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
¹⁷ Department of Pathology, University of South Florida, Tampa, Florida; Department of Pathology, Moffitt Cancer Center, Tampa, Florida.
¹⁸ Private practice, Yorba Linda, California.
¹⁹ Private practice, Towson, MD.
²⁰ Dermatology Section, NEOMED, Rootstown, Ohio.
²¹ Geisinger Medical Center, Danville, Maryland.
²² Memorial Sloan-Kettering, New York, New York.
²³ Basal Cell Carcinoma Nevus Syndrome Life Support Network, Burton, Ohio.
²⁴ Mayo Clinic, Phoenix, Arizona.
²⁵ Stanford School of Medicine, Stanford, California.
²⁶ Dermatologic Surgery and Laser Center, University of California San Francisco, San Francisco, California.
²⁷ Department of Dermatology, University of Alabama, Birmingham, Alabama.
²⁸ American Academy of Dermatology, Schaumburg, IL.
²⁹ American Academy of Dermatology, Schaumburg, IL. Electronic address: wsmithbegolka@aad.org.
³⁰ Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

PMID: 29331386
PMCID: PMC6652228
DOI: 10.1016/j.jaad.2017.10.007

Practice Guideline

Guidelines of care for the management of cutaneous squamous cell carcinoma

Work Group et al. J Am Acad Dermatol. 2018 Mar.

. 2018 Mar;78(3):560-578.

doi: 10.1016/j.jaad.2017.10.007. Epub 2018 Jan 10.

Authors

Work Group; Invited Reviewers; John Y S Kim¹, Jeffrey H Kozlow², Bharat Mittal³, Jeffrey Moyer⁴, Thomas Olenecki⁵, Phillip Rodgers⁶

Collaborators

Murad Alam⁷, April Armstrong⁸, Christian Baum⁹, Jeremy S Bordeaux¹⁰, Marc Brown¹¹, Klaus J Busam¹², Daniel B Eisen¹³, Vivek Iyengar¹⁴, Clifford Lober¹⁵, David J Margolis¹⁶, Jane Messina¹⁷, Alexander Miller¹⁸, Stanley Miller¹⁹, Eliot Mostow²⁰, Christen Mowad²¹, Kishwer Nehal²², Kristi Schmitt-Burr²³, Aleksandar Sekulic²⁴, Paul Storrs¹⁴, Joyce Teng²⁵, Siegrid Yu²⁶, Conway Huang²⁷, Kevin Boyer²⁸, Wendy Smith Begolka²⁹, Christopher Bichakjian³⁰

Affiliations

¹ Department of Plastic and Reconstructive Surgery, Northwestern University, Chicago, Illinois.
² Section of Plastic and Reconstructive Surgery, University of Michigan, Ann Arbor, Michigan.
³ Department of Radiation Oncology, Northwestern University, Chicago, Illinois.
⁴ Department of Otolaryngology, Plastic/Head/Neck Surgery, University of Michigan, Ann Arbor, Michigan.
⁵ Department of Internal Medicine, Ohio State University, Columbus, Ohio.
⁶ Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.
⁷ Department of Dermatology, Northwestern University, Chicago, Illinois.
⁸ Department of Dermatology, University of Colorado, Denver, Colorado.
⁹ Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
¹⁰ Case Western Reserve University School of Medicine, Cleveland, Ohio.
¹¹ Department of Dermatology, University of Rochester, Rochester, Minnesota.
¹² Dermatopathology, Memorial Sloan-Kettering, New York, New York.
¹³ Department of Dermatology, University of California Davis, Sacramento, California.
¹⁴ Private practice, Chicago, Illinois.
¹⁵ Private practice, Kissimmee, Florida.
¹⁶ University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
¹⁷ Department of Pathology, University of South Florida, Tampa, Florida; Department of Pathology, Moffitt Cancer Center, Tampa, Florida.
¹⁸ Private practice, Yorba Linda, California.
¹⁹ Private practice, Towson, MD.
²⁰ Dermatology Section, NEOMED, Rootstown, Ohio.
²¹ Geisinger Medical Center, Danville, Maryland.
²² Memorial Sloan-Kettering, New York, New York.
²³ Basal Cell Carcinoma Nevus Syndrome Life Support Network, Burton, Ohio.
²⁴ Mayo Clinic, Phoenix, Arizona.
²⁵ Stanford School of Medicine, Stanford, California.
²⁶ Dermatologic Surgery and Laser Center, University of California San Francisco, San Francisco, California.
²⁷ Department of Dermatology, University of Alabama, Birmingham, Alabama.
²⁸ American Academy of Dermatology, Schaumburg, IL.
²⁹ American Academy of Dermatology, Schaumburg, IL. Electronic address: wsmithbegolka@aad.org.
³⁰ Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

PMID: 29331386
PMCID: PMC6652228
DOI: 10.1016/j.jaad.2017.10.007

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human cancer and has an increasing annual incidence. Although most cSCC is cured with office-based therapy, advanced cSCC poses a significant risk for morbidity, impact on quality of life, and death. This document provides evidence-based recommendations for the management of patients with cSCC. Topics addressed include biopsy techniques and histopathologic assessment, tumor staging, surgical and nonsurgical management, follow-up and prevention of recurrence, and management of advanced disease. The primary focus of these recommendations is on evaluation and management of primary cSCC and localized disease, but where relevant, applicability to recurrent cSCC is noted, as is general information on the management of patients with metastatic disease.

Keywords: biopsy; curettage; metastasis; phototherapy; radiotherapy; squamous cell carcinoma; staging; surgery; surveillance; topical therapy.

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Conflict of interest statement

The management of conflict of interests for this guideline series complies with the Council of Medical Special Societies’ Code of Interactions with Companies. The authors’ conflict of interest/ disclosure statements appear at the end of this article.

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References

1. Bichakjian C, Armstrong A, Baum C, et al. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol Online ahead of print. 10.1016/j.jaad.2017.10.006. - DOI - PubMed
1. National Comprehensive Cancer Center. NCCN clinical practice guidelines in oncology; squamous cell carcinoma (V12015). Available at: www.nccn.org. Accessed April 1, 2015.
1. National Comprehensive Cancer Center. NCCN clinical practice guidelines in oncology; squamous cell carcinoma (V1.2017) Available at: www.nccn.org. Accessed October 3, 2016.
1. Motley R, Kersey P, Lawrence C. Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma. Br J Dermatol 2002;146(1):18–25. - PubMed
1. Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. J Am Board Fam Pract 2004;17(1):59–67. - PubMed

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[1] Bichakjian C, Armstrong A, Baum C, et al. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol Online ahead of print. 10.1016/j.jaad.2017.10.006. - DOI - PubMed

[2] Bichakjian C, Armstrong A, Baum C, et al. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol Online ahead of print. 10.1016/j.jaad.2017.10.006. - DOI - PubMed

[3] National Comprehensive Cancer Center. NCCN clinical practice guidelines in oncology; squamous cell carcinoma (V12015). Available at: www.nccn.org. Accessed April 1, 2015.

[4] National Comprehensive Cancer Center. NCCN clinical practice guidelines in oncology; squamous cell carcinoma (V12015). Available at: www.nccn.org. Accessed April 1, 2015.

[5] National Comprehensive Cancer Center. NCCN clinical practice guidelines in oncology; squamous cell carcinoma (V1.2017) Available at: www.nccn.org. Accessed October 3, 2016.

[6] National Comprehensive Cancer Center. NCCN clinical practice guidelines in oncology; squamous cell carcinoma (V1.2017) Available at: www.nccn.org. Accessed October 3, 2016.

[7] Motley R, Kersey P, Lawrence C. Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma. Br J Dermatol 2002;146(1):18–25. - PubMed

[8] Motley R, Kersey P, Lawrence C. Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma. Br J Dermatol 2002;146(1):18–25. - PubMed

[9] Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. J Am Board Fam Pract 2004;17(1):59–67. - PubMed

[10] Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. J Am Board Fam Pract 2004;17(1):59–67. - PubMed

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Guidelines of care for the management of cutaneous squamous cell carcinoma

Collaborators

Affiliations

Guidelines of care for the management of cutaneous squamous cell carcinoma

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

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Cited by

References

Publication types

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Grants and funding

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Full Text Sources

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Medical

Abstract

Conflict of interest statement

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Grants and funding

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Medical