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. 2017 Oct-Dec;38(4):456-460.
doi: 10.4103/ijmpo.ijmpo_169_16.

Squamous Cell Carcinoma Lung with Skeletal Muscle Involvement: A 8-year Study of a Tertiary Care Hospital in Kashmir

Javvid Muzamil  1 , Shumail Bashir  2 , Faisal R Guru  1 , Firdousa Nabi  3 , Gull Mohammad Bhat  1
Affiliations

Squamous Cell Carcinoma Lung with Skeletal Muscle Involvement: A 8-year Study of a Tertiary Care Hospital in Kashmir

Javvid Muzamil et al. Indian J Med Paediatr Oncol. 2017 Oct-Dec.

Abstract

Aims: Lung cancer is the most common malignancy throughout the world. Nonsmall cell lung cancer (NSCLC) is the most common type, and squamous cell type is most common in India. Mostly, patients present with chest-related symptoms and signs. Isolated skeletal muscle metastasis (ISMM) is rarely seen. The aim was to see muscle metastasis and its prognosis.

Materials and methods: We are presenting our data of 8 years about this common malignancy with relation to muscle metastasis, either alone or with other system metastasis.

Results: Muscle metastasis is seen 1.5% of patients, with male: female of 8:1. Overall median survival was 15 months and progression-free survival was 12 months.

Conclusion: One peculiarity seen was ISMM with no pulmonary system and severe paraneoplastic hypercalcemia. Local therapy may be having an impact on overall survival in metachronous muscle involvement.

Keywords: Cytokeratin; isolated skeletal muscle metastasis; nonsmall cell lung carcinoma; overall survival; parathyroid hormone-related peptide; progression-free survival; superior vena cava; thyroid transcription factor.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Contrast-enhanced computed tomography chest showing left hilar mass
Figure 2
Figure 2
Contrast-enhanced computed tomography showing (a) huge lung mass with necrosis (b) multiple liver metastases
Figure 3
Figure 3
Histopathology showing squamous cell carcinoma of lung
Figure 4
Figure 4
Bone metastases in Tibia with sclerosis around lytic lesion
Figure 5
Figure 5
Contrast-enhanced computed tomography showing (a) Iliacus muscle involvement (b) biopsy of same muscle revealing squamous cell carcinoma metastases
See this image and copyright information in PMC

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