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. 2018 Jun;32(5):e22385.
doi: 10.1002/jcla.22385. Epub 2018 Jan 15.

Surrogate scale for evaluating respiratory function based on complete blood count parameters

Yang Guang  1 , Zhou Jie  1 , Dong Feng  1 , Liu Hui  1
Affiliations

Surrogate scale for evaluating respiratory function based on complete blood count parameters

Yang Guang et al. J Clin Lab Anal. 2018 Jun.

Abstract

Background: In this study, we aimed to identify a simple method for evaluating respiratory function using complete blood count parameters.

Methods: The complete blood count parameters, including red blood cell (RBC) count, hemoglobin (Hb) level, lymphocyte (Lym) and platelet (Plt) count, and partial pressure of oxygen (PO2 ) level, were measured using automated analyzers in patients with chronic obstructive pulmonary disease (COPD), aged subjects, and young subjects (control group). The red cell index (RCI) was calculated using the following equation: (RBC × Hb)/(Lym × Plt); in theory, the RCI is inversely proportional to the respiratory function.

Results: We observed a significant relationship between the RCI and PCO2 values, and between the RCI and FEV1/FVC values (P < .05). The RCI in the COPD, and aged subject groups were all significantly higher than that in the control group (P < .05). The cutoff value for normal respiratory function was 2.3. The positive rates for an abnormal increase in RCI were also considerably higher in each observation group than in the control group (P < .05).

Conclusion: The RCI can be considered as a simple and effective tool for evaluating respiratory function.

Keywords: COPD; blood count; computer-assisted diagnosis; respiratory function.

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Figures

Figure 1
Figure 1
ROC curve for various cutoff levels of the RCI between COPD and control group. AUC: area under the curve; RCI: the red cell index
See this image and copyright information in PMC

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