Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke

Katherine M Crawford¹, Cristina Gallego-Fabrega¹, Christina Kourkoulis¹, Laura Miyares¹, Sandro Marini¹, Jason Flannick¹, Noel P Burtt¹, Marcin von Grotthuss¹, Benjamin Alexander¹, Maria C Costanzo¹, Neil H Vaishnav¹, Rainer Malik¹, Jennifer L Hall¹, Michael Chong¹, Jonathan Rosand², Guido J Falcone¹; International Stroke Genetics Consortium

Affiliations

¹ From the Center for Genomic Medicine (K.C., C.G.-F., C.K., S.M., N.V., J.R.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (J.R.), and J. Philip Kistler Stroke Research Center (J.R.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (K.C., C.G.-F., C.K., S.M., J.F., N.B., M.v.G., B.A., M.C., N.V., J.R., G.J.F.); Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., G.J.F.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilian University, Munich, Germany (R.M.); Institute for Precision Cardiovascular Medicine, American Heart Association National Center, Dallas, TX (J.L.H.); Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (J.L.H.); and McMaster University, Hamilton, Ontario, Canada (M.C.).
² From the Center for Genomic Medicine (K.C., C.G.-F., C.K., S.M., N.V., J.R.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (J.R.), and J. Philip Kistler Stroke Research Center (J.R.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (K.C., C.G.-F., C.K., S.M., J.F., N.B., M.v.G., B.A., M.C., N.V., J.R., G.J.F.); Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., G.J.F.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilian University, Munich, Germany (R.M.); Institute for Precision Cardiovascular Medicine, American Heart Association National Center, Dallas, TX (J.L.H.); Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (J.L.H.); and McMaster University, Hamilton, Ontario, Canada (M.C.). jrosand@partners.org guido.falcone@yale.edu.

PMID: 29335331
PMCID: PMC5780219
DOI: 10.1161/STROKEAHA.117.018922

Review

Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke

Katherine M Crawford et al. Stroke. 2018 Feb.

. 2018 Feb;49(2):470-475.

doi: 10.1161/STROKEAHA.117.018922. Epub 2018 Jan 15.

Authors

Affiliations

¹ From the Center for Genomic Medicine (K.C., C.G.-F., C.K., S.M., N.V., J.R.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (J.R.), and J. Philip Kistler Stroke Research Center (J.R.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (K.C., C.G.-F., C.K., S.M., J.F., N.B., M.v.G., B.A., M.C., N.V., J.R., G.J.F.); Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., G.J.F.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilian University, Munich, Germany (R.M.); Institute for Precision Cardiovascular Medicine, American Heart Association National Center, Dallas, TX (J.L.H.); Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (J.L.H.); and McMaster University, Hamilton, Ontario, Canada (M.C.).
² From the Center for Genomic Medicine (K.C., C.G.-F., C.K., S.M., N.V., J.R.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (J.R.), and J. Philip Kistler Stroke Research Center (J.R.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (K.C., C.G.-F., C.K., S.M., J.F., N.B., M.v.G., B.A., M.C., N.V., J.R., G.J.F.); Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., G.J.F.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilian University, Munich, Germany (R.M.); Institute for Precision Cardiovascular Medicine, American Heart Association National Center, Dallas, TX (J.L.H.); Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (J.L.H.); and McMaster University, Hamilton, Ontario, Canada (M.C.). jrosand@partners.org guido.falcone@yale.edu.

PMID: 29335331
PMCID: PMC5780219
DOI: 10.1161/STROKEAHA.117.018922

No abstract available

Keywords: cause of death; cerebral hemorrhage; humans; research; stroke.

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Conflict of interest statement

Conflicts of Interest / Disclosures

None.

Figures

**Figure 1**
Number of genome-wide significant loci for different complex traits.

**Figure 2**
Data access through the CDKP. Data flow describes the generalized path that all data take through the CDKP. The End-User Experience details how a user interacts with the resources. Summary level data can be access through the CDKP’s web based GUI designed to run queries and allow for download of data while Individual level data can be accessed through the PMP to run custom analysis.

**Figure 3**
Subject overlap across the datasets within the CDKP.

See this image and copyright information in PMC

References

1. The top 10 causes of death. World Health Organization; Jan, 2017. [Accessed March 15, 2017]. http://www.who.int/mediacentre/factsheets/fs310/en/
1. Hankey GJ. Stroke. The Lancet. 2017;389:641–654. - PubMed
1. Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and stroke statistics—2017 update: A report from the american heart association. Circulation. 2017;135:e146–e603. - PMC - PubMed
1. Bevan S, Traylor M, Adib-Samii P, Malik R, Paul NL, Jackson C, et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. Stroke. 2012;43:3161–3167. - PubMed
1. Traylor M, Rutten-Jacobs LC, Holliday EG, Malik R, Sudlow C, Rothwell PM, et al. Differences in common genetic predisposition to ischemic stroke by age and sex. Stroke. 2015;46:3042–3047. - PMC - PubMed

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Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke

Affiliations

Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke

Authors

Affiliations

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical