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Review
. 2018 May;53(5):521-534.
doi: 10.1038/s41409-017-0062-8. Epub 2018 Jan 15.

The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Stefan O Ciurea  1 , Kai Cao  2 , Marcelo Fernandez-Vina  3 , Piyanuch Kongtim  4 , Monzr Al Malki  5 , Ephraim Fuchs  6 , Leo Luznik  6 , Xiao-Jun Huang  7 , Fabio Ciceri  8 , Franco Locatelli  9 , Franco Aversa  10 , Luca Castagna  11 , Andrea Bacigalupo  12 , Massimo Martelli  13 , Didier Blaise  14 , Rupert Handgretinger  15 , Denis-Claude Roy  16 , Paul O'Donnell  17 , Asad Bashey  18 , Hillard M Lazarus  19 , Karen Ballen  20 , Bipin N Savani  21 , Mohamad Mohty  22 , Arnon Nagler  23   24
Affiliations
Review

The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Stefan O Ciurea et al. Bone Marrow Transplant. 2018 May.

Erratum in

Abstract

Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

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Conflict of interest statement

Conflict of interest: The authors have no competing financial interests to disclose for this work.

Figures

Figure 1.
Figure 1.
Survival of haploidentical transplants for patients who experience primary graft failure as compared with those who engrafted the donor cells (Reproduced with permission from Ciurea SO, et al. Biol Blood Marrow Transplant. 2015)
Figure 2.
Figure 2.
Desensitization approach for patients with DSAs undergoing haploidentical stem cell transplantation at MD Anderson Cancer Center (Reproduced with permission from Kongtim P, et al. Advances in hematology.2016)
See this image and copyright information in PMC

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