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Review
. 2018 Sep;20(9):1153-1160.
doi: 10.1007/s12094-018-1832-5. Epub 2018 Jan 15.

Pancreaticoduodenectomy for periampullary tumours: a review article based on Surveillance, End Results and Epidemiology (SEER) database

S K Kamarajah  1
Affiliations
Review

Pancreaticoduodenectomy for periampullary tumours: a review article based on Surveillance, End Results and Epidemiology (SEER) database

S K Kamarajah. Clin Transl Oncol. 2018 Sep.

Abstract

Introduction: This study set to examine relative survival of patients with periampullary cancers undergoing pancreaticoduodenectomy (PD).

Methods: Using the Surveillance, End Results and Epidemiology (SEER) database, this study identified 9877 patients with non-metastatic pancreatic adenocarcinoma who underwent PD between 2004 and 2013.

Results: Ampullary carcinomas have the best survival among periampullary malignancies. Lymph node ratio is a significant prognostic factor, even when stratified by tumour types. Patients receiving adjuvant radiotherapy following PD have superior survival than patients without radiotherapy (median 25 vs 20 months, p < 0.001), particularly ductal adenocarcinoma (HR: 0.74, CI95% 0.69-0.78; p < 0.001), cholangiocarcinoma (HR: 0.75, CI95% 0.59-0.97; p = 0.027), and ampullary carcinoma (HR: 0.79, CI95% 0.64-0.98; p = 0.029) with greatest survival benefit at 1-year postresection.

Conclusion: Future studies aiming to further define genetic signatures of individual periampullary cancers would allow a personalised therapeutic approach in improving survival.

Keywords: Outcomes; Pancreaticoduodenectomy; Resection; SEER; Survival.

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