Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

doi:10.1007/s12035-018-0869-3

Review

. 2018 Aug;55(8):6700-6711.

doi: 10.1007/s12035-018-0869-3. Epub 2018 Jan 15.

Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

Cristhian Mendoza¹, George E Barreto^{2

3}, Alexandre Iarkov¹, Vadim V Tarasov⁴, Gjumrakch Aliev^{5

6

7}, Valentina Echeverria^{8

9}

Affiliations

¹ Facultad de Ciencias de la Salud, Universidad San Sebastián, Lientur 1457, 4030000, Concepción, Chile.
² Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
³ Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.
⁴ Institute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
⁵ Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Severniy Proezd, Chernogolovka, Moscow Region, 1142432, Russia. aliev03@gmail.com.
⁶ "GALLY" International Biomedical Research Consulting LLC, San Antonio, TX, 78229, USA. aliev03@gmail.com.
⁷ School of Health Sciences and Healthcare Administration, University of Atlanta, Johns Creek, GA, 30097, USA. aliev03@gmail.com.
⁸ Facultad de Ciencias de la Salud, Universidad San Sebastián, Lientur 1457, 4030000, Concepción, Chile. echeverria.valentina@gmail.com.
⁹ Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL, 33744, USA. echeverria.valentina@gmail.com.

PMID: 29335846
DOI: 10.1007/s12035-018-0869-3

Review

Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

Cristhian Mendoza et al. Mol Neurobiol. 2018 Aug.

. 2018 Aug;55(8):6700-6711.

doi: 10.1007/s12035-018-0869-3. Epub 2018 Jan 15.

Authors

Cristhian Mendoza¹, George E Barreto^{2

3}, Alexandre Iarkov¹, Vadim V Tarasov⁴, Gjumrakch Aliev^{5

6

7}, Valentina Echeverria^{8

9}

Affiliations

¹ Facultad de Ciencias de la Salud, Universidad San Sebastián, Lientur 1457, 4030000, Concepción, Chile.
² Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
³ Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.
⁴ Institute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
⁵ Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Severniy Proezd, Chernogolovka, Moscow Region, 1142432, Russia. aliev03@gmail.com.
⁶ "GALLY" International Biomedical Research Consulting LLC, San Antonio, TX, 78229, USA. aliev03@gmail.com.
⁷ School of Health Sciences and Healthcare Administration, University of Atlanta, Johns Creek, GA, 30097, USA. aliev03@gmail.com.
⁸ Facultad de Ciencias de la Salud, Universidad San Sebastián, Lientur 1457, 4030000, Concepción, Chile. echeverria.valentina@gmail.com.
⁹ Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL, 33744, USA. echeverria.valentina@gmail.com.

PMID: 29335846
DOI: 10.1007/s12035-018-0869-3

Erratum in

Correction to: Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder.
Mendoza C, Barreto GE, Iarkov A, Tarasov VV, Aliev G, Echeverria V. Mendoza C, et al. Mol Neurobiol. 2018 Aug;55(8):6712. doi: 10.1007/s12035-018-1094-9. Mol Neurobiol. 2018. PMID: 29700774

Abstract

Post-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed. The role of the positive modulation by cotinine of the nicotinic acetylcholine receptors (nAChRs) and their downstream effectors, the protection of astroglia, and the inhibition of microglia in the PTSD brain are also discussed.

Keywords: Cotinine; Extinction; Fear; Inflammation; Nicotinic receptor; Post-traumatic stress disorder.

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Cited by

The Walking Wounded: Emerging Treatments for PTSD.
Bestha D, Soliman L, Blankenship K, Rachal J. Bestha D, et al. Curr Psychiatry Rep. 2018 Sep 14;20(10):94. doi: 10.1007/s11920-018-0941-8. Curr Psychiatry Rep. 2018. PMID: 30218438 Review.
Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases.
Echeverria V, Mendoza C, Iarkov A. Echeverria V, et al. Front Neurosci. 2023 May 15;17:1179611. doi: 10.3389/fnins.2023.1179611. eCollection 2023. Front Neurosci. 2023. PMID: 37255751 Free PMC article. Review.
Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions.
Tan X, Vrana K, Ding ZM. Tan X, et al. Front Behav Neurosci. 2021 Oct 21;15:758252. doi: 10.3389/fnbeh.2021.758252. eCollection 2021. Front Behav Neurosci. 2021. PMID: 34744656 Free PMC article. Review.
Impaired learning, memory, and extinction in posttraumatic stress disorder: translational meta-analysis of clinical and preclinical studies.
Sep MSC, Geuze E, Joëls M. Sep MSC, et al. Transl Psychiatry. 2023 Dec 7;13(1):376. doi: 10.1038/s41398-023-02660-7. Transl Psychiatry. 2023. PMID: 38062029 Free PMC article.
(E)-Nicotinaldehyde O-Cinnamyloxime, a Nicotine Analog, Attenuates Neuronal Cells Death Against Rotenone-Induced Neurotoxicity.
Jurado-Coronel JC, Loaiza AE, Díaz JE, Cabezas R, Ashraf GM, Sahebkar A, Echeverria V, González J, Barreto GE. Jurado-Coronel JC, et al. Mol Neurobiol. 2019 Feb;56(2):1221-1232. doi: 10.1007/s12035-018-1163-0. Epub 2018 Jun 7. Mol Neurobiol. 2019. PMID: 29881944

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[1] PLoS One. 2013 Dec 09;8(12):e81585 - PubMed

[2] PLoS One. 2013 Dec 09;8(12):e81585 - PubMed

[3] Behav Brain Res. 2012 Mar 17;228(2):284-93 - PubMed

[4] Behav Brain Res. 2012 Mar 17;228(2):284-93 - PubMed

[5] J Circadian Rhythms. 2007 Feb 12;5:3 - PubMed

[6] J Circadian Rhythms. 2007 Feb 12;5:3 - PubMed

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[9] Biol Psychiatry. 2003 Feb 1;53(3):204-10 - PubMed

[10] Biol Psychiatry. 2003 Feb 1;53(3):204-10 - PubMed

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Cotinine: A Therapy for Memory Extinction in Post-traumatic Stress Disorder

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