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Comment
. 2018 Mar;28(3):263-264.
doi: 10.1038/cr.2018.12. Epub 2018 Jan 16.

Anti-PD1 in the wonder-gut-land

Marie Vetizou  1 , Giorgio Trinchieri  1
Affiliations
Comment

Anti-PD1 in the wonder-gut-land

Marie Vetizou et al. Cell Res. 2018 Mar.

Abstract

After the initial success of cancer immunotherapy using immune checkpoint blockers, the challenge is to understand why only a minority of patients respond to the therapy and to increase the rate of response. Three recent papers now report that the gut microbiota modulates the response to anti-PD1 therapy in patients with epithelial cancers or melanoma.

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Figures

Figure 1
Figure 1
The composition of the fecal microbiota is regulated by the genetics, lifestyle and treatment history of the cancer patients. Three recent papers show that the gut microbiota modulates the ability of the patients to respond to anti-PD1 immunotherapy, may be used as an independent biomarker to predict responsiveness and in the future may be possibly targeted to improve the proportion of patients able to respond.
See this image and copyright information in PMC

Comment on

  • Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.
    Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, Cogdill AP, Zhao L, Hudgens CW, Hutchinson DS, Manzo T, Petaccia de Macedo M, Cotechini T, Kumar T, Chen WS, Reddy SM, Szczepaniak Sloane R, Galloway-Pena J, Jiang H, Chen PL, Shpall EJ, Rezvani K, Alousi AM, Chemaly RF, Shelburne S, Vence LM, Okhuysen PC, Jensen VB, Swennes AG, McAllister F, Marcelo Riquelme Sanchez E, Zhang Y, Le Chatelier E, Zitvogel L, Pons N, Austin-Breneman JL, Haydu LE, Burton EM, Gardner JM, Sirmans E, Hu J, Lazar AJ, Tsujikawa T, Diab A, Tawbi H, Glitza IC, Hwu WJ, Patel SP, Woodman SE, Amaria RN, Davies MA, Gershenwald JE, Hwu P, Lee JE, Zhang J, Coussens LM, Cooper ZA, Futreal PA, Daniel CR, Ajami NJ, Petrosino JF, Tetzlaff MT, Sharma P, Allison JP, Jenq RR, Wargo JA. Gopalakrishnan V, et al. Science. 2018 Jan 5;359(6371):97-103. doi: 10.1126/science.aan4236. Epub 2017 Nov 2. Science. 2018. PMID: 29097493 Free PMC article.
  • Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
    Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L. Routy B, et al. Science. 2018 Jan 5;359(6371):91-97. doi: 10.1126/science.aan3706. Epub 2017 Nov 2. Science. 2018. PMID: 29097494
  • The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
    Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre ML, Luke JJ, Gajewski TF. Matson V, et al. Science. 2018 Jan 5;359(6371):104-108. doi: 10.1126/science.aao3290. Science. 2018. PMID: 29302014 Free PMC article.

References

    1. Rizvi NA, Hellman MD, Snyder A, et al. Science 2015; 348:124–128. - PMC - PubMed
    1. Viaud S, Saccheri F, Mignot G, et al. Science 2013; 342:971–976. - PMC - PubMed
    1. Iida N, Dzutsev A, Stewart CA, et al. Science 2013; 342:967–970. - PMC - PubMed
    1. Vétizou M, Pitt JM, Daillère R, et al. Science 2015; 350:1079–1084. - PMC - PubMed
    1. Sivan A, Corrales L, Hubert N, et al. Science 2015; 350:1084–1089. - PMC - PubMed

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