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Review
. 2018 Mar;23(3):727-735.
doi: 10.1016/j.drudis.2018.01.035. Epub 2018 Jan 11.

Progress with covalent small-molecule kinase inhibitors

Zheng Zhao  1 , Philip E Bourne  2
Affiliations
Free article
Review

Progress with covalent small-molecule kinase inhibitors

Zheng Zhao et al. Drug Discov Today. 2018 Mar.
Free article

Abstract

With reduced risk of toxicity and high selectivity, covalent small-molecule kinase inhibitors (CSKIs) have emerged rapidly. Through the lens of structural system pharmacology, here we review this rapid progress by considering design strategies and the challenges and opportunities offered by current CSKIs.

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