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. 2018 Jan 16;12(1):e0006208.
doi: 10.1371/journal.pntd.0006208. eCollection 2018 Jan.

Occupational exposure to human Mycobacterium bovis infection: A systematic review

Flora Vayr  1 , Guillaume Martin-Blondel  2   3 , Frederic Savall  4   5 , Jean-Marc Soulat  1   6 , Gaëtan Deffontaines  7 , Fabrice Herin  1   6
Affiliations

Occupational exposure to human Mycobacterium bovis infection: A systematic review

Flora Vayr et al. PLoS Negl Trop Dis. .

Abstract

Background: Mycobacterium bovis (M. bovis) is the main causative agent of bovine zoonotic tuberculosis. The aim of this systematic review is to highlight the occupational exposure to bovine tuberculosis due to M. bovis.

Methodology/principal findings: A computer based literature search was carried out to identify papers published between January 2006 and March 2017. "PubMed, Cochrane Library and Science Direct" databases were searched systematically. Articles presenting the following properties were included: (i) focusing on M. bovis; (ii) concerning occupational exposure to bovine tuberculosis. A quality assessment was performed after selection of studies. Our search strategy identified a total of 3,264 papers of which 29 studies met the inclusion criteria. Of the 29 articles, 17 were cross-sectional studies (6 were of high quality and scored in the range of 6-7, 11 were of moderate quality and scored in the range 3-5), 10 were case reports, and 2 were reviews. Different occupational fields exposing to the disease were described: livestock sector, particularly in contact with dairy cattle (farmers, veterinaries and assistants, abattoir workers) and working in contact with wildlife (hunters, taxidermists).

Conclusions: A specific guideline for occupational practitioners taking care of employees exposed to bovine tuberculosis is warranted and should be tailored to level of exposure. This review was intended to be the first step of such a project. Articles were identified from various continents and countries with different socio-economic situations, broadening our understanding of the worldwide situation. Published data on occupational exposure in developed countries are scarce. We had to extrapolate findings from countries with higher prevalence of the disease.

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. de la Rua-Domenech R. Human Mycobacterium bovis infection in the United Kingdom: Incidence, risks, control measures and review of the zoonotic aspects of bovine tuberculosis. Tuberculosis. 2006. March;86(2):77–109. doi: 10.1016/j.tube.2005.05.002 - DOI - PubMed
    1. Ayele WY, Neill SD, Zinsstag J, Weiss MG, Pavlik I. Bovine tuberculosis: an old disease but a new threat to Africa. Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis. 2004. August;8(8):924–37. - PubMed
    1. Smith I. Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev. 2003. July;16(3):463–96. doi: 10.1128/CMR.16.3.463-496.2003 - DOI - PMC - PubMed
    1. Magnus K. Epidemiological basis of tuberculosis eradication. 3. Risk of pulmonary tuberculosis after human and bovine infection. Bull World Health Organ. 1966;35(4):483–508. - PMC - PubMed
    1. Hlavsa MC, Moonan PK, Cowan LS, Navin TR, Kammerer JS, Morlock GP, et al. Human tuberculosis due to Mycobacterium bovis in the United States, 1995–2005. Clin Infect Dis Off Publ Infect Dis Soc Am. 2008. July 15;47(2):168–75. - PubMed

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