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Review
. 2018 Jan 16;11(1):10.
doi: 10.1186/s13045-017-0549-1.

Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel

J Caers  1 , B Paiva  2 , E Zamagni  3 , X Leleu  4 , J Bladé  5 , S Y Kristinsson  6 , C Touzeau  7 , N Abildgaard  8 , E Terpos  9 , R Heusschen  10 , E Ocio  11 , M Delforge  12 , O Sezer  13 , M Beksac  14 , H Ludwig  15 , G Merlini  16 , P Moreau  7 , S Zweegman  17 , M Engelhardt  18 , L Rosiñol  5
Affiliations
Review

Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel

J Caers et al. J Hematol Oncol. .

Abstract

Solitary plasmacytoma is an infrequent form of plasma cell dyscrasia that presents as a single mass of monoclonal plasma cells, located either extramedullary or intraosseous. In some patients, a bone marrow aspiration can detect a low monoclonal plasma cell infiltration which indicates a high risk of early progression to an overt myeloma disease. Before treatment initiation, whole body positron emission tomography-computed tomography or magnetic resonance imaging should be performed to exclude the presence of additional malignant lesions. For decades, treatment has been based on high-dose radiation, but studies exploring the potential benefit of systemic therapies for high-risk patients are urgently needed. In this review, a panel of expert European hematologists updates the recommendations on the diagnosis and management of patients with solitary plasmacytoma.

Keywords: Extramedullary plasmacytoma; MRI; Myeloma; PET/CT; Plasma cell dyscrasia; Radiotherapy; Solitary plasmacytoma.

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Conflict of interest statement

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Not applicable

Consent for publication

Not applicable

Competing interests

Jo Caers received honoraria from Amgen, Celgene, and Janssen-Cilag and research grants from Celgene. Elena Zamagni received honoraria from Janssen-Cilag, Celgene, BMS, and Amgen. Niels Abdilgaard received research grants from Takeda, Celgene, and Amgen and honoraria from Takeda, Celgene, and Janssen-Cilag. Xavier Leleu received honoraria from Janssen-Cilag, Celgene, Novartis, Sanofi, Amgen, Takeda, Pierre Fabre, Gilead, BMS, and Merck. Laura Rosinol received honoraria from Janssen, Celgene, Amgen, and Takeda. The other authors declare that they have no competing interests.

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References

    1. Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos M-V, Kumar S, Hillengass J, Kastritis E, Richardson P, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15:e538–e548. doi: 10.1016/S1470-2045(14)70442-5. - DOI - PubMed
    1. Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R. Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Blood. 2000;96:2037–2044. - PubMed
    1. Liebross RH, Ha CS, Cox JD, Weber D, Delasalle K, Alexanian R. Clinical course of solitary extramedullary plasmacytoma. Radiother Oncol. 1999;52:245–249. doi: 10.1016/S0167-8140(99)00114-0. - DOI - PubMed
    1. Nahi H, Genell A, Walinder G, Uttervall K, Juliusson G, Karin F, Hansson M, Svensson R, Linder O, Carlson K, et al. Incidence, characteristics, and outcome of solitary plasmacytoma and plasma cell leukemia. Population-based data from the Swedish Myeloma Register. Eur J Haematol. 2017;99:216–222. doi: 10.1111/ejh.12907. - DOI - PubMed
    1. Ozsahin M, Tsang RW, Poortmans P, Belkacemi Y, Bolla M, Dincbas FO, Landmann C, Castelain B, Buijsen J, Curschmann J, et al. Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients. Int J Radiat Oncol Biol Phys. 2006;64:210–217. doi: 10.1016/j.ijrobp.2005.06.039. - DOI - PubMed

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