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. 2018 Feb;19(2):110-116.
doi: 10.14744/AnatolJCardiol.2017.8160. Epub 2018 Jan 17.

Association of serum prolidase activity in patients with isolated coronary artery ectasia

Erdal Aktürk, Lütfü Aşkın  1 , Hüseyin Nacar, M Hakan Taşolar, Serdar Türkmen, Mustafa Çetin, Mehmet Bozkurt
Affiliations

Association of serum prolidase activity in patients with isolated coronary artery ectasia

Erdal Aktürk et al. Anatol J Cardiol. 2018 Feb.

Abstract

Objective: Coronary artery ectasia (CAE) is defined as an angiographic enlargement of a portion of the coronary artery between 1.5 and 2 times the diameter of the adjacent normal coronary artery. It has been demonstrated that increased serum prolidase activity (SPA) is associated with increased collagen turnover. We aimed to analyze the relationship between CAE and serum SPA levels.

Methods: This study used a prospective case protocol design. A total of 40 consecutive patients with isolated right CAE and normal coronary arteries (23 men, 17 women; mean age, 62.4±10.8 years) were evaluated. The control group included the same number of consecutive patients with angiographically normal coronary arteries (20 men, 20 women; mean age, 63.8±11.1 years). Clinical characteristics, laboratory results, cardiovascular risk factors, and medication use were recorded. SPA was measured using a spectrophotometer. Student's t-test, Mann-Whitney U test, chi-square test, Pearson's and Spearman's correlations, logistic regression analysis, and ROC curve analysis were used for statistical analysis.

Results: SPA was significantly higher in the CAE group compared with the control group (1635.2±492.0 U/L and 986.2±422.3 U/L, respectively; p<0.001). The relationship of SPA with CAE proved to be significant (r=0.512; p<0.001). SPA also served as an independent predictor of CAE (OR=1.003; 95% CI, 1.001-1.005; p=0.002). The SPA value of 1170 U/L was predictive of CAE, with a sensitivity of 85% and specificity of 60% (AUC=0.854; 95% CI, 0.763-0.944; p<0.001).

Conclusion: The activity of this enzyme was significantly correlated with CAE.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Serum prolidase activity levels between the groups
Figure 2
Figure 2
Correlation between serum prolidase activity and left ventri-cular ejection fraction
Figure 3
Figure 3
Receiver operating characteristic curve for the determination of the cut-off for serum prolidase activity in the prediction for coronary artery ectasia
See this image and copyright information in PMC

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References

    1. Krüger D, Stierle U, Herrmann G, Simon R, Sheikhzadeh A. Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (“dilated coronaropathy”) J Am Coll Cardiol. 1999;34:1461–70. - PubMed
    1. Yamanaka O, Hobbs RE. Coronary artery anomalies in 126,595 patients undergoing coronary arteriography. Cathet Cardiovasc Diagn. 1990;21:28–40. - PubMed
    1. Pinar Bermúdez E, López Palop R, Lozano Martínez-Luengas I, Cortés Sánchez R, Carrillo Sáez P, Rodríguez Carreras R, et al. Coronary ectasia:prevalence, and clinical and angiographic characteristics. Rev Esp Cardiol. 2003;56:473–9. - PubMed
    1. Sayin T, Döven O, Berkalp B, Akyürek O, Güleç S, Oral D. Exercise-induced myocardial ischemia in patients with coronary artery ectasia without obstructive coronary artery disease. Int J Cardiol. 2001;78:143–9. - PubMed
    1. Maehara A, Mintz GS, Ahmed JM, Fuchs S, Castagna MT, Pichard AD, et al. An intravascular ultrasound classification of angiographic coronary artery aneurysms. Am J Cardiol. 2001;88:365–70. - PubMed

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