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Comparative Study
. 2018 Mar;50(3):541-549.
doi: 10.1007/s11255-018-1785-1. Epub 2018 Jan 16.

Application of automated peritoneal dialysis in urgent-start peritoneal dialysis patients during the break-in period

Shengmao Liu  1 , Xiaohua Zhuang  1 , Min Zhang  1 , Yanfeng Wu  1 , Min Liu  1 , Sibo Guan  1 , Shujun Liu  1 , Lining Miao  1 , Wenpeng Cui  2
Affiliations
Comparative Study

Application of automated peritoneal dialysis in urgent-start peritoneal dialysis patients during the break-in period

Shengmao Liu et al. Int Urol Nephrol. 2018 Mar.

Abstract

Objective: Whether automated peritoneal dialysis (APD) is a feasible strategy for urgent-start peritoneal dialysis (PD) therapy during the break-in period remains unclear. This study was conducted to compare the efficacy as well as complications among three PD modes during the break-in period.

Methods: Ninety-six patients treated with urgent-start PD after catheterization were retrospectively analyzed. Patients were divided into three groups, incremental continuous ambulatory PD (CAPD) group (n = 26); APD group (n = 42); and APD-CAPD group (n = 28). Clinical parameters at the end of the break-in period and 1 month after the initiation of PD treatment were collected and analyzed.

Results: Compared with the traditional incremental CAPD, APD and APD-CAPD were superior as they could effectively remove small-molecule uremic toxins and correct electrolyte imbalance (P < 0.05), while did not increase the incidence of early complications during the break-in period (P > 0.05). However, APD led to a significant decline in albumin and pre-albumin, as compared with APD-CAPD and CAPD (P < 0.05). A PD strategy consisting 6 days of APD and 3 days of CAPD showed a great advantage in preventing excessive protein loss. There were no significant differences in all tested biochemical parameters among the three groups at 1 month after treatment (all P > 0.05).

Conclusion: Application of APD for urgent-start PD during the break-in period is feasible. A combination of APD and CAPD regimens seems to be a more reasonable mode.

Keywords: Automated peritoneal dialysis; Break-in period; Continuous ambulatory peritoneal dialysis; Peritoneal dialysis.

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Conflict of interest statement

Conflict of interest

All the authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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