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. 2018 Feb 19;57(8):2032-2034.
doi: 10.1002/anie.201712185. Epub 2018 Jan 17.

Development of Antibody-Directed Therapies: Quo Vadis?

Tiago Rodrigues  1 , Gonçalo J L Bernardes  1   2
Affiliations

Development of Antibody-Directed Therapies: Quo Vadis?

Tiago Rodrigues et al. Angew Chem Int Ed Engl. .

Abstract

Less is more: The efficacy of antibody-drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties can afford more stable and effective ADCs.

Keywords: anti-tumor agents; antibody-drug conjugates; bioconjugation; drug delivery; linkers.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Common linkers used in ADCs and their drug‐release mechanisms.
Figure 2
Figure 2
ADCs with non‐cleavable linker and release mechanism of the payloads. Payloads for which the strategy has been validated are depicted. Image compiled by Claudia Flandoli.
See this image and copyright information in PMC

References

    1. Atkins J. H., Gershell L. J., Nat. Rev. Drug Discovery 2002, 1, 491–492. - PubMed
    1. None
    1. Beck A., Goetsch L., Dumontet C., Corvaia N., Nat. Rev. Drug Discovery 2017, 16, 315–337; - PubMed
    1. Beck A., Haeuw J. F., Wurch T., Goetsch L., Bailly C., Corvaia N., Discovery Med. 2010, 10, 329–339. - PubMed
    1. Krall N., da Cruz F. P., Boutureira O., Bernardes G. J., Nat. Chem. 2016, 8, 103–113. - PubMed

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